| Basic data |
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| OCA1. Surname awarded to the assessed person | Trbolová |
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| OCA2. Name awarded to the assessed person | Alexandra |
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| OCA3. Degrees awarded to the assessed person | Prof. , DVM, PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6048 |
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| OCA5. Area of assessment | study programme general veterinary medicine · I. + II. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2025 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | 1315240 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=2898A0C014A2DECFD793CD229F61https://app.crepc.sk/?fn=detailBiblioForm&sid=2898A0C014A2DECFD793CD229F61 |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://arl4.library.sk/arl-uvlk/sk/detail/?zf=SHORT&idx=uvlk_un_cat*0045729&iset=2&disprec=21 |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | GÁBOR, Michal - CANDRÁK, Juraj - MILUCHOVÁ, Martina - ZUBRICKÝ, Pavol - BALICKA, Agnieszka Alexandra - TRBOLOVÁ, Alexandra. Initial genome-wide case–Control study for genetic background of retinal dysplasia in Czechoslovakian Wolfdog. In Veterinary sciences. ISSN 2306-7381, 2025, vol. 12, no. 2, art. no. 171, p. [1-10]. (2025: 2.7 - IF, 2.8 - IF 5y, 47 - H-index, 0.653 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q, 1 - Nordic list). Dostupné na internete: . |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.mdpi.com/2306-7381/12/2/171 |
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| OCA14. Characteristics of the author's contribution | The author conducted the clinical portion of the research, oversaw the laboratory analyses, and collected data. She was also responsible for supervising the project. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | A scientific study identified the occurrence of multifocal retinal dysplasia in the Czechoslovakian Wolfdog breed and, using a genome-wide association study (GWAS), localized the genetic association to the CFA37 chromosome in the CYP27A1 gene. The results suggest that multiple genes may be involved simultaneously in the development of this complex disease, which changes our understanding of eye health in this breed. |
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| Other data |
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| OCA16. Annotation of the output in English | Retinal dysplasia is a complex canine eye disease that is determined by a combination of genetic and non-genetic risk factors. The genetic basis of retinal dysplasia in specific canine breeds remains incompletely understood. While the Czechoslovakian Wolfdog is generally known for being free of significant eye problems, our research has shown that multifocal retinal dysplasia can occur in this breed. A clinical study of 117 Czechoslovakian Wolfdogs found six samples with symptoms of multifocal retinal dysplasia. A genome-wide case–control association study of 36 adult dogs identified association on chromosome CFA37, specifically in the first intron of the CYP27A1 gene. The region of this gene is very interesting because other genes linked to ocular diseases in animal models are localized in this locus. It suggests the possibility of multiple genes contributing to the multiple retinal dysplasia phenotype in Czechoslovakian Wolfdogs. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | |
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| OCA18. Characteristics of the output's impact on socio-economic practice | A study on retinal dysplasia in the Czechoslovakian Wolfdog has direct implications for breeding and veterinary practice by identifying the genetic basis (a locus on chromosome CFA37 and the CYP27A1 gene) of the disease. The study confirmed a 5.13% prevalence of multifocal retinal dysplasia in the examined sample, which enables targeted selection and prevention in breeding programs. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | The findings of the study on retinal dysplasia in the Czechoslovak Wolfdog and related scientific activities make a significant contribution to higher education and academic practice. This publication serves as a foundation for the advancement of specialized knowledge in the fields of veterinary ophthalmology and genetics. |
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