| Basic data |
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| OCA1. Surname awarded to the assessed person | Trbolová |
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| OCA2. Name awarded to the assessed person | Alexandra |
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| OCA3. Degrees awarded to the assessed person | Prof. , DVM, PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6048 |
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| OCA5. Area of assessment | study programme veterinary nurse · I. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2024 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | 1171216 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=6B68A92B6F46FD75E864E059F860 |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://arl4.library.sk/arl-uvlk/sk/detail-uvlk_un_cat-0043758-Effect-of-butorphanolmedetomidine-and-butorphanoldexmedetomidine-on-echocardiographic-parameters-d/?disprec=40&iset=2&pg=4 |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | BOČKAY, Andrej - AGUDELO RAMÍREZ, Carlos Fernando - FIGUROVÁ, Mária - VARGOVÁ, Nela - TRBOLOVÁ, Alexandra. Effect of butorphanol-medetomidine and butorphanol-dexmedetomidine on echocardiographic parameters during propofol anaesthesia in dogs. In Animals. ISSN 2076-2615, 2024, vol. 14, no. 9, art. no. 1379, p. [1-10]. (2024: 2.7 - IF, 3.2 - IF 5y, 95 - H-index, 0.733 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q, 1 - Nordic list). (2024 - Current Contents). Dostupné na internete: . |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://pubmed.ncbi.nlm.nih.gov/38731383/ |
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| OCA14. Characteristics of the author's contribution | The author is involved in a study - in clinical practice: Medetomidine and dexmedetomidine, commonly used in veterinary practice, induce sedation, muscle relaxation, and analgesia. Decreased heart rate is one of the most common side effects of these anesthetics. Adverse effects include increased vascular resistance, impaired further perfusion of some tissues, and decreased cardiac output. These effects can be fatal in the critically ill patient. The aim of this study was to compare the hemodynamic depressant effects of butorphanol-medetomidine and butorphanol-dexmedetomidine combinations on echocardiographic parameters during propofol anesthesia in dogs and to determine which anesthetic is less likely to attenuate cardiovascular effects. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | This study compared the effects of butorphanol-medetomidine and butorphanol-dexmedetomidine combinations on echocardiographic parameters during propofol anaesthesia in dogs. The dogs were randomly divided into two groups. In the butorphanol-medetomidine (BM) group, butorphanol (0.2 mg/kg) and medetomidine (15 μg/kg) were intravenously administered; in the butorphanol-dexmedetomidine (BD) group, butorphanol (0.2 mg/kg) and dexmedetomidine (7.5 μg/kg) was used. Anaesthesia was induced with propofol and maintained with a constant-rate infusion of propofol (0.2 mg/kg/min). The echocardiographic parameters were assessed in conscious dogs (T0). Echocardiography was conducted again at 10 min post premedication (T1), followed by assessments at 30 (T2), 60 (T3), and 90 (T4) mins. The dogs were subjected to diagnostic procedures (radiography, computed tomography) under anaesthesia. A significant reduction in heart rate and cardiac output was noted in both groups at T1. There was no significant difference in the stroke volume between the BM and BD groups. The application of butorphanol-dexmedetomidine caused a significant increase in the left ventricular internal diameter in diastole and the diameter of the left atrium compared to that caused by butorphanol-medetomidine. This study documented that butorphanol-medetomidine and butorphanol-dexmedetomidine combinations caused similar reductions in heart rate and cardiac output in both groups. ‘New´ valvular regurgitation occurred following their administration. |
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| Other data |
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| OCA16. Annotation of the output in English | Medetomidine and dexmedetomidine, commonly used in veterinary practice, induce sedation, muscle relaxation and analgesia. Reduced heart rate is one of the most common side effects of these anaesthetics. Other undesirable effects include increased vascular resistance, deterioration of blood supply to some tissues, and a decrease in cardiac output. These effects can be fatal in a critically ill patient. This study aimed to compare the haemodynamically depressive effects of butorphanol-medetomidine and butorphanol-dexmedetomidine combinations on echocardiographic parameters during propofol anaesthesia in dogs and to determine which anaesthetic produces fewer adverse cardiovascular effect. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | ÇETINKAYA, Mehmet Alper - KAYA, Mahir. The effects of propofol on Doppler echocardiographic values of the aorta, main pulmonary artery, and mitral E wave in New Zealand white rabbits. In Thai Journal of Veterinary Medicine, 2024-10-01, 54, 4, pp. ISSN 01256491. Dostupné na: https://doi.org/10.56808/2985-1130.3710.
ZALISCHI, Diana-Bianca - CATANA, Laura - STEFANUT, Laura-Cristina - POPESCU, Andra - IOZON, Ilinca - MUNTEAN, Andreea - CERNEA, Mihai. Overdose Effects of Medetomidine and Fentanyl in Rats: Reflex, Vital and Analgesic Parameters as Predictive Markers. In VETERINARY MEDICINE-RESEARCH AND REPORTS, 2026, vol. 17, no., pp. Dostupné na: https://doi.org/10.2147/VMRR.S572918., Registrované v: WOS
ABASS, Marwa - HAMED, Mohamed - ELNAFARAWY, Helmy K. - FARAG, Alshimaa M. Echocardiographic effects of medetomidine, butorphanol, and their combination in donkeys. In BMC Veterinary Research, 2026-12-01, 22, 1, pp. Dostupné na: https://doi.org/10.1186/s12917-026-05678-3., Registrované v: SCOPUS
SCHIESARI, Camilla - TUCCI, Luigi - COSTA, Arianna - VENTURA, Laura - BERTOLINI, Giovanna - BORTOLAMI, Elisa. Anaesthetic Management Including Low-Dose Dexmedetomidine and Butorphanol in Dogs Undergoing ECG-Gated Cardiac Computed Tomography: A Retrospective Case Series. In VETERINARY SCIENCES, 2026, vol. 13, no. 8, pp. Dostupné na: https://doi.org/10.3390/vetsci13080767., Registrované v: WOS |
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| OCA18. Characteristics of the output's impact on socio-economic practice | study demonstrated that the intravenous administration of butorphanol-medetomidine and butorphanol-dexmedetomidine combination caused similar reductions in HR, CO and incidence of ‘new’ valvular regurgitation during propofol-maintained general anaesthesia. The butorphanol-dexmedetomidine combination may induce greater enlargement of the left side of the heart (LVIDd and LA Diam) than does butorphanol-medetomidine. Propofol may also negatively affect systolic and diastolic heart functions. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | The results are primarily used in the educational process, but mainly in outpatient clinical practice |
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