NOSÁLOVÁ, Natália - HUNIADI, Mykhailo - HORŇÁKOVÁ, Ľubica - VALENČÁKOVÁ, Alexandra - HORŇÁK, Slavomír - NAGOOS, Kamil - VOZÁR, Juraj - ČÍŽKOVÁ, Dáša. Canine mammary tumors: Classification, biomarkers, traditional and personalised therapies. In: International Journal of Molecular Sciences. ISSN 1422-0067, Vol. 25, No. 5 (2024), art. no. 2891, p. [1-26]

Basic data
OCA1. Surname awarded to the assessed person	Horňáková
OCA2. Name awarded to the assessed person	Ľubica
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6074
OCA5. Area of assessment	study programme cynology · I. degree
OCA6. Category of the research/artistic/other output	professional output
OCA7. Year of publication of the research/artistic/other output	2024
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID = 1154896
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=366D98E0417739F5215FB674A316
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://arl4.library.sk/arl-uvlk/sk/detail-uvlk_un_cat-0043577-Canine-mammary-tumors-Classification-biomarkers-traditional-and-personalized-therapies/?disprec=1&iset=1
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	NOSÁLOVÁ, Natália - HUNIADI, Mykhailo - HORŇÁKOVÁ, Ľubica - VALENČÁKOVÁ, Alexandra - HORŇÁK, Slavomír - NAGOOS, Kamil - VOZÁR, Juraj - ČÍŽKOVÁ, Dáša. Canine mammary tumors: Classification, biomarkers, traditional and personalised therapies. In: International Journal of Molecular Sciences. ISSN 1422-0067, Vol. 25, No. 5 (2024), art. no. 2891, p. [1-26]
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.mdpi.com/1422-0067/25/5/2891
OCA14. Characteristics of the author's contribution	The author had a significant influence on the creation and content of the publication. She significantly contributed to the acquisition and completion of biological material.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	Many studies have focused on the dog as a suitable animal model for human cancer. In dogs, mammary gland tumours develop spontaneously, which involves a complex interaction between tumour cells and the immune system and reveals several molecular and clinical similarities with human breast cancer. In this review, we summarise the main features of canine mammary tumours, risk factors, and the most important biomarkers used for diagnosis and treatment. Traditional therapy for canine mammary tumours includes surgery, chemotherapy, radiotherapy, or hormonal therapy. However, these therapeutic strategies may not always be sufficient on their own; advances in understanding cancer mechanisms and the development of innovative treatments offer hope for improved outcomes for cancer patients. There is growing interest in the use of personalised medicine, which should play an irreplaceable role in research, not only in human cancer treatment, but also in veterinary oncology. In addition, immunotherapy may represent a new and promising therapeutic option for canine mammary cancer.
Other data
OCA16. Annotation of the output in English	In recent years, many studies have focused their attention on the dog as a proper animal model for human cancer. In dogs, mammary tumours develop spontaneously, involving a complex interplay between tumour cells and the immune system and revealing several molecular and clinical similarities to human breast cancer. In this review, we summarised the major features of canine mammary tumours, risk factors, and the most important biomarkers used for diagnosis and treatment. Traditional therapy of mammary tumours in dogs includes surgery, chemotherapy, radiotherapy, or hormonal therapy. However, these therapeutic strategies may not always be sufficient on their own; advancements in understanding cancer mechanisms and the development of innovative treatments offer hope for improved outcomes for oncologic patients. There is still a growing interest in the use of personalised medicine, which should play an irreplaceable role in research, not only in human cancer therapy, but also in veterinary oncology. Moreover, immunotherapy may represent a novel and promising therapeutic option in canine mammary cancers.
OCA17. List of maximum 5 most significant citations corresponding to the output	BHUTTA, Zeeshan Ahmad - CHOI, Kyung Chul. Canine mammary tumors as a promising adjunct preclinical model for human breast cancer research: similarities, opportunities, and challenges. In Archives of Pharmacal Research, 2025-01-01, 48, 1, pp. 43-61. ISSN 02536269. Dostupné na: https://doi.org/10.1007/s12272-024-01524-y. GLIKIN, Gerardo C. - FINOCCHIARO, Liliana M.E. Clinical Trials of Cancer Immunogene Therapies in Companion Animals: An Update (2017–2024). In Veterinary Sciences, 2025-04-01, 12, 4, pp. Dostupné na: https://doi.org/10.3390/vetsci12040329. MEI, Chen - LIU, Ying - LIU, Zhenyi - ZHI, Yan - JIANG, Zhaoling - LYU, Xueze - WANG, Hongjun. Dysregulated Signaling Pathways in Canine Mammary Tumor and Human Triple Negative Breast Cancer: Advances and Potential Therapeutic Targets. In International Journal of Molecular Sciences, 2025-01-01, 26, 1, pp. ISSN 16616596. Dostupné na: https://doi.org/10.3390/ijms26010145. MIRANDA, Fernanda Freitas - GARCIA, Ana Paula Vargas - DOS REYS, Marina Possa - VISCONE, Erica Almeida - FLECHER, Mayra Cunha - RODRIGUES, Michele Angela - CASSALI, Geovanni Dantas. The Number and Size of Invasion Areas in Mixed-Type Carcinoma in Female Dogs Are Associated with Regional Metastases. In Veterinary Sciences, 2025-04-01, 12, 4, pp. Dostupné na: https://doi.org/10.3390/vetsci12040318. SRISAWAT, Wanwisa - KOONYOSYING, Pongpisid - MUENTHAISONG, Anucha - SANGKAKAM, Kanokwan - VARINRAK, Thanya - STHITMATEE, Nattawooti. Preliminary Exploration of MAGE-B1,B4,B5, andB10 mRNA Expression in Canine Mammary Tumors in Dogs. In Animals, 2025-04-01, 15, 7, pp. Dostupné na: https://doi.org/10.3390/ani15070910.
OCA18. Characteristics of the output's impact on socio-economic practice	The study of novel therapeutic approaches is essential for future research in both human and veterinary oncology, which is of great importance for socio-economic and economic practice.
OCA19. Characteristics of the output and related activities' impact on the educational process	The research findings offer new insights into the potential for diagnosing mammary gland tumours in veterinary medicine, which are utilised in the pedagogical process and subsequently applied in the clinical practice of small animals.