| Basic data |
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| OCA1. Surname awarded to the assessed person | Horňáková |
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| OCA2. Name awarded to the assessed person | Ľubica |
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| OCA3. Degrees awarded to the assessed person | Assoc. prof. , DVM, PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6074 |
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| OCA5. Area of assessment | study programme cynology · I. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2023 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | ID = 1054110 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=C9F2ED9DAFACD725E46459E63EB7 |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://arl4.library.sk/arl-uvlk/sk/vysledky/?field=TITLE&term=Impact+of+canine+amniotic+mesenchymal+stem+cell+conditioned+media+on+the+wound+healing+process%3A+In+vitro+and+in+vivo+study&search=H%C4%BEada%C5%A5&op=result&zf=&sort=&guide= |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | HUMENÍK, Filip - MALOVESKÁ, Marcela - HUDÁKOVÁ, Nikola - PETROUŠKOVÁ, Patrícia - ŠUFLIARSKA, Zuzana - HORŇÁKOVÁ, Ľubica - VALENČÁKOVÁ, Alexandra - KOŽÁR, Martin - ŠIŠKOVÁ, Barbora - MUDROŇOVÁ, Dagmar - BARTKOVSKÝ, Martin - ČÍŽKOVÁ, Dáša. Impact of canine amniotic mesenchymal stem cell conditioned media on the wound healing process: In vitro and in vivo study. In: International Journal of Molecular Sciences. 2023. ISSN 1422-0067, Vol. 24, No. 9 (2023), art. No. 8214, p. [1-14]
(2022: 5.600 - IF, 230 - H-index, 6.200 - IF 5y, 1.154 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q) |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.mdpi.com/1422-0067/24/9/8214 |
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| OCA14. Characteristics of the author's contribution | The author had a significant influence on the creation and content of the publication. She significantly contributed to the collection of biological material and subsequent in vivo studies. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | This study aimed to demonstrate the beneficial therapeutic effect of canine amniotic membrane-derived mesenchymal stem cell (AM-MSC) products on the complicated wound healing process in dogs. AM-MSCs were characterised in terms of morphology, phenotypic profile and multilineage differentiation potential.
An in vitro efficacy study was performed with conditioned media from canine amniotic mesenchymal stem cells (AMMSC-CM) on a primary skin fibroblast cell culture. |
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| Other data |
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| OCA16. Annotation of the output in English | This study aimed to provide a beneficial treatment effect of mesenchymal stem cell products derived from the canine amniotic membrane (AM-MSC) on the complicated wound healing process in dogs. AM-MSCs were characterised in terms of morphology, phenotypic profile, and multilineage differentiation potential. The in vitro study of the effect of canine amniotic mesenchymal stem cell conditioned media (AMMSC-CM) on a primary skin fibroblast cell culture scratch assay showed a decrease in the measured scratch area of about 66.39% against the negative and positive control after 72 h of treatment. In the experimental study, seven dogs with complicated non-healing wounds were treated with a combination of antibiotics, NSAIDs, and local AMMSC-CM application. After 15 days of therapy, we observed a 98.47% reduction in the wound surface area as opposed to 57.135% in the control group treated by conventional therapy based on debridement of necrotic tissue, antibiotic therapy, pain management, and change of wound dressing. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | CHAE, Chang Woo - KIM, Dae Hyun - JO, Hyo Youn - OH, Yeon Ju - LEE, Hyun Jik. Exosomes-based applications in companion animals: Diagnostics and therapeutics in dogs and cats. In Journal of Drug Delivery Science and Technology, 2025-06-01, 108, pp. ISSN 17732247. Dostupné na: https://doi.org/10.1016/j.jddst.2025.106958.
MAKSIMOVA, M.A. - KOROCHKINA, E.A. Derivatives of mesenchymal stromal cells: methods of preparation and scope of application in veterinary medicine (review). In Legal regulation in veterinary medicine. ISSN 2782-6252, 2024, vol. ,no. 2, p. 75-80.
PICAZO, Rosa Ana - ROJO, Concepción - RODRIGUEZ-QUIROS, Jesus - GONZÁLEZ-GIL, Alfredo. Current Advances in Mesenchymal Stem Cell Therapies Applied to Wounds and Skin, Eye, and Neuromuscular Diseases in Companion Animals. In Animals, 2024-05-01, 14, 9, pp. Dostupné na: https://doi.org/10.3390/ani14091363. |
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| OCA18. Characteristics of the output's impact on socio-economic practice | The confirmed results are of great importance for socio-economic and economic practice in veterinary and human medicine. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | The research results are used in the pedagogical process in the theoretical part and the outpatient practice of small animals, especially in wound healing therapy. |
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