PETROUŠKOVÁ, Patrícia - PELEGRINOVÁ, Andrea - DRÁŽOVSKÁ, Monika - ONDREJKOVÁ, Anna - KORYTÁR, Ľuboš - PROKEŠ, Marián - VOJTEK, Boris - MOJŽIŠOVÁ VAŠČINEC, Jana - MANDELÍK, René. Acute hemorrhagic gastroenteritis caused by an “Asian” CPV-2c variant in a vaccinated dog from Slovakia (Central Europe): a case report. In Frontiers in veterinary science. ISSN 2297-1769, 2026, vol. 13, no., art. no. 1864309, p. [1-8]. (2024: 2.9 - IF, 3.3 - IF 5y, 85 - H-index, 0.783 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q, 1 - Nordic list). Dostupné na internete: .

Basic data
OCA1. Surname awarded to the assessed personOndrejková
OCA2. Name awarded to the assessed personAnna
OCA3. Degrees awarded to the assessed personProf. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staffhttps://www.portalvs.sk/regzam/detail/2007
OCA5. Area of assessmentstudy programme infectious diseases of animals · III. degree
OCA6. Category of the research/artistic/other outputscientific output
OCA7. Year of publication of the research/artistic/other output2026
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)1599383
OCA9. Hyperlink to the record in CRPA or CRAAhttps://app.crepc.sk/?fn=detailBiblioForm&sid=BCCBB3B3C2736EEF32B625DA1FA0
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputsPETROUŠKOVÁ, Patrícia - PELEGRINOVÁ, Andrea - DRÁŽOVSKÁ, Monika - ONDREJKOVÁ, Anna - KORYTÁR, Ľuboš - PROKEŠ, Marián - VOJTEK, Boris - MOJŽIŠOVÁ VAŠČINEC, Jana - MANDELÍK, René. Acute hemorrhagic gastroenteritis caused by an “Asian” CPV-2c variant in a vaccinated dog from Slovakia (Central Europe): a case report. In Frontiers in veterinary science. ISSN 2297-1769, 2026, vol. 13, no., art. no. 1864309, p. [1-8]. (2024: 2.9 - IF, 3.3 - IF 5y, 85 - H-index, 0.783 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q, 1 - Nordic list). Dostupné na internete: .
OCA12. Type of the output (if the output is not registered in CRPA or CRAA) article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1864309/full
OCA14. Characteristics of the author's contributionSupervision, Writing – review & editing, Methodology
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.An 8-month-old vaccinated male English Cocker Spaniel was presented with hemorrhagic diarrhea, vomiting, and lethargy. Canine parvovirus (CPV-2) infection was indicated by a weakly positive rapid antigen test and confirmed by a combination of serological, molecular, and virological methods. Serological analysis revealed a high IgM titer (1:2,700) and the absence of IgG antibodies, while hemagglutination inhibition (HI) and serum neutralization tests (SNT) confirmed the presence of functional antibodies (≥1:640). Molecular characterization based on the VP2 gene (1,755 bp) identified the CPV-2c variant with amino acid signatures (5Gly, 267Tyr, 324Ile, 370Arg, and 440Thr) typical of the “Asian” lineage. The virus was successfully isolated in A-72 cell culture with characteristic cytopathic effects (CPE). Following intensive supportive therapy, the dog was discharged in stable condition. This report provides molecular evidence of the circulation of “Asian” CPV-2c variants in Central Europe and highlights the importance of comprehensive diagnostic approaches in vaccinated dogs
Other data
OCA16. Annotation of the output in EnglishThis case highlights that CPV-2 infection should remain an important differential diagnosis in dogs presenting with compatible clinical signs, regardless of vaccination status. The combined use of molecular, virological, and serological methods proved essential for accurate diagnosis, particularly in cases with inconclusive antigen test results. The detection of an “Asian” CPV-2c lineage in Slovakia (Central Europe) further supports the ongoing expansion of this variant in Europe and highlights the importance of continuous molecular surveillance and monitoring of circulating CPV-2 strains even in vaccinated individuals.
OCA17. List of maximum 5 most significant citations corresponding to the output
OCA18. Characteristics of the output's impact on socio-economic practiceThis report provides molecular evidence of the circulation of “Asian” CPV-2c variants in Central Europe and highlights the importance of comprehensive diagnostic approaches in vaccinated dogs.
OCA19. Characteristics of the output and related activities' impact on the educational processThe obtained results are utilized in the study of immunology, epizootiology, and the immunoprophylaxis of infectious animal diseases.

Last updated: 28.10.2026

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