The role of primed and non-primed MSC-derived conditioned media in neuroregeneration / Hudáková, Nikola [Autor, 35%] ; Mudroňová, Dagmar [Autor, 5%] ; Marcinčáková, Dana [Autor, 5%] ; Slovinská, Lucia [Autor, 5%] ; Majerová, Petra [Autor, 5%] ; Maloveská, Marcela [Autor, 10%] ; Petroušková, Patrícia [Autor, 5%] ; Humeník, Filip [Autor, 5%] ; Čížková, Daša [Autor, 25%]. – [recenzované]. – DOI 10.3389/fnmol.2023.1241432. – CCC ; SCO ; WOS CC. In: Frontiers in molecular neuroscience [elektronický dokument] . – Lausanne (Švajčiarsko) : Frontiers Research Foundation. – ISSN (online) 1662-5099. – Roč. 16 (2023), art. no.1241432, s. [1-15] [online]

Basic data
OCA1. Surname awarded to the assessed person	Čížková
OCA2. Name awarded to the assessed person	Daša
OCA3. Degrees awarded to the assessed person	Prof. , DVM, DrSc.
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6154
OCA5. Area of assessment	habilitation and inauguration procedure – microbiology and immunology
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2023
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID: 1095671
OCA9. Hyperlink to the record in CRPA or CRAA
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	The role of primed and non-primed MSC-derived conditioned media in neuroregeneration / Hudáková, Nikola [Autor, 35%] ; Mudroňová, Dagmar [Autor, 5%] ; Marcinčáková, Dana [Autor, 5%] ; Slovinská, Lucia [Autor, 5%] ; Majerová, Petra [Autor, 5%] ; Maloveská, Marcela [Autor, 10%] ; Petroušková, Patrícia [Autor, 5%] ; Humeník, Filip [Autor, 5%] ; Čížková, Daša [Autor, 25%]. – [recenzované]. – DOI 10.3389/fnmol.2023.1241432. – CCC ; SCO ; WOS CC. In: Frontiers in molecular neuroscience [elektronický dokument] . – Lausanne (Švajčiarsko) : Frontiers Research Foundation. – ISSN (online) 1662-5099. – Roč. 16 (2023), art. no.1241432, s. [1-15] [online]
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1241432/full
OCA14. Characteristics of the author's contribution	The authors\' contribution consisted of comparing the biological effects of conditioned media from MSCs of various origins and evaluating the impact of cytokine priming on their proteome and regenerative effects on neuronal cells.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	This output is based on an experimental comparison of conditioned media from canine MSCs isolated from various tissues and their effects on the proliferation, metabolic activity, neuritogenesis, and regeneration of damaged neuronal cells, including an assessment of changes following IFN-γ priming.
Other data
OCA16. Annotation of the output in English	he study provides a comparative evaluation of conditioned media (CM) derived from canine mesenchymal stem cells (MSCs) of adipose and amniotic membrane origin, focusing on their protein composition and regenerative, immunomodulatory, and neuroprotective effects. The findings demonstrate tissue source-dependent biological activity and show that IFN-γ priming modifies the CM proteomic profile and enhances selected effects on neuronal cells, supporting its potential for therapeutic applications.
OCA17. List of maximum 5 most significant citations corresponding to the output	1. 2026: [1] ABEDI, Azam - FOROUTAN, Tahereh - DARGAHI, Leila. Intranasal CM-hMSCs modulate brain gene expression linked to glucose metabolism and inflammation in male and female rats exposed to maternal and post-weaning high-fat diets. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2026, vol. 399, no. 7, pp. 10761-10776. ISSN 0028-1298. Dostupné na: https://doi.org/10.1007/s00210-026-05068-4. 2. 2025: [3] Sand T. A survey of the composition, safety, efficacy and regulation of non-autologous biologic treatments in human musculoskeletal pathologies. Exploration of Musculoskeletal Diseases. ISSN 2836-6468, 2025, vol. 3, no., art. no. 100795, p. [1-22].
OCA18. Characteristics of the output's impact on socio-economic practice	The outcome may contribute to the development of more effective MSC-based therapeutic approaches in veterinary medicine and to the standardization of conditioned media production using a suitable MSC source and optimized priming.
OCA19. Characteristics of the output and related activities' impact on the educational process	The output expands educational knowledge in the fields of regenerative medicine, cell therapy, and the use of MSC-derived conditioned media in regeneration and neuroprotection.