Impact of amniotic stem cell-conditioned medium on tear film integrity and MMP-9 levels in canine dry eye syndrome / Balicka, Agnieszka Alexandra [Autor, 17%] ; Hudáková, Nikola [Autor, 10%] ; Lapšanská, Mária [Autor, 9%] ; Rašiová, Adriana [Autor, 10%] ; Trbolová, Alexandra [Autor, 5%] ; Tomečková, Vladimíra [Autor, 12%] ; Kondrakhova, Daria M. [Autor, 5%] ; Komanický, Vladimír [Autor, 3%] ; Večurkovská, Ivana [Autor, 5%] ; Bober, Peter [Autor, 3%] ; Horňáková, Ľubica [Autor, 4%] ; Vikartovská, Zuzana [Autor, 3%] ; Čížková, Daša [Korešpondenčný autor, 14%]. – [recenzované]. – DOI 10.1016/j.exer.2025.110736. – SCO ; WOS CC ; CCC. In: Experimental eye research [textový dokument (print)] [elektronický dokument] . – Londýn (Veľká Británia) : Elsevier. Academic Press. – ISSN 0014-4835. – ISSN (online) 1096-0007. – č. 262 (2026), art. no. 110736, s. [1-10] [tlačená forma] [online] Verejná poznámka: DIGARCHUPJS

Basic data
OCA1. Surname awarded to the assessed person	Čížková
OCA2. Name awarded to the assessed person	Daša
OCA3. Degrees awarded to the assessed person	Prof. , DVM, DrSc.
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6154
OCA5. Area of assessment	habilitation and inauguration procedure – microbiology and immunology
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2026
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID: 1467703
OCA9. Hyperlink to the record in CRPA or CRAA
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://pubmed.ncbi.nlm.nih.gov/41207525/
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	Impact of amniotic stem cell-conditioned medium on tear film integrity and MMP-9 levels in canine dry eye syndrome / Balicka, Agnieszka Alexandra [Autor, 17%] ; Hudáková, Nikola [Autor, 10%] ; Lapšanská, Mária [Autor, 9%] ; Rašiová, Adriana [Autor, 10%] ; Trbolová, Alexandra [Autor, 5%] ; Tomečková, Vladimíra [Autor, 12%] ; Kondrakhova, Daria M. [Autor, 5%] ; Komanický, Vladimír [Autor, 3%] ; Večurkovská, Ivana [Autor, 5%] ; Bober, Peter [Autor, 3%] ; Horňáková, Ľubica [Autor, 4%] ; Vikartovská, Zuzana [Autor, 3%] ; Čížková, Daša [Korešpondenčný autor, 14%]. – [recenzované]. – DOI 10.1016/j.exer.2025.110736. – SCO ; WOS CC ; CCC. In: Experimental eye research [textový dokument (print)] [elektronický dokument] . – Londýn (Veľká Británia) : Elsevier. Academic Press. – ISSN 0014-4835. – ISSN (online) 1096-0007. – č. 262 (2026), art. no. 110736, s. [1-10] [tlačená forma] [online] Verejná poznámka: DIGARCHUPJS
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://pubmed.ncbi.nlm.nih.gov/41207525/
OCA14. Characteristics of the author's contribution	The authors\' contribution involved the design and implementation of an experimental evaluation of eye drops based on conditioned medium from amniotic membrane stem cells (AMSCCM) for the treatment of keratoconjunctivitis sicca in dogs. They participated in assessing tear production and inflammatory and regenerative parameters of the tear film—including MMP-9 and total protein content—as well as in analyzing its structure using AFM.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	This output resulted from the experimental evaluation of the effects of eye drops containing conditioned medium from amniotic membrane stem cells in dogs with KCS, utilizing clinical, biochemical, and AFM methods to assess the therapeutic response.
Other data
OCA16. Annotation of the output in English	The study investigated the therapeutic potential of eye drops containing conditioned media derived from canine amniotic stem cells (AMSCCM) in dogs with qualitative keratoconjunctivitis sicca (KCS). The treatment response was evaluated using clinical, biochemical, and atomic force microscopy (AFM) analyses of tear production, inflammatory markers, and tear film morphology.
OCA17. List of maximum 5 most significant citations corresponding to the output
OCA18. Characteristics of the output's impact on socio-economic practice	Výstup môže prispieť k vývoju novej biologickej a regeneratívnej terapie kvalitatívnej keratoconjunctivitis sicca u psov, najmä u pacientov nedostatočne reagujúcich na konvenčnú liečbu.
OCA19. Characteristics of the output and related activities' impact on the educational process	This output advances educational knowledge in the fields of veterinary ophthalmology, regenerative medicine, and the use of cellular products for treating ocular surface diseases. The insights gained and the methodological approaches employed can serve as a practical basis for teaching the diagnosis, assessment of inflammation, and monitoring of therapeutic response in cases of KCS in dogs.