PLACHÁ, Iveta [40 %] - BAČOVÁ, Kristína [20 %] - ZITTERL-EGLSEER, Karin [10 %] - LAUKOVÁ, Andrea [10 %] - CHRASTINOVÁ, Ľubica [5 %] - MAĎAROVÁ, Michaela [5 %] - ŽITŇAN, Rudolf [5 %] - ŠTRKOLCOVÁ, Gabriela [5 %]. Thymol in fattening rabbit diet, its bioavailability and effects on intestinal morphology, microbiota from caecal content and immunity. In Journal of Animal Physiology and Animal Nutrition. ISSN 0931-2439, 2022, vol. 106, no. 2, p. 368-377. (2021: 2.718 - IF, 2.747 - IF 5y, 58 - H-index, 0.592 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q). Dostupné na internete: .

Basic data
OCA1. Surname awarded to the assessed person	Štrkolcová
OCA2. Name awarded to the assessed person	Gabriela
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/26622
OCA5. Area of assessment	habilitation and inauguration procedure – food hygiene and the environment
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2022
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	DOI10.1111/jpn.13595
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioFormChildCDK31&sid=37166900746EB0FDFAC2857C9A&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.sciencedirect.com/science/article/pii/S1876034120304433?via%3Dihub
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	PLACHÁ, Iveta [40 %] - BAČOVÁ, Kristína [20 %] - ZITTERL-EGLSEER, Karin [10 %] - LAUKOVÁ, Andrea [10 %] - CHRASTINOVÁ, Ľubica [5 %] - MAĎAROVÁ, Michaela [5 %] - ŽITŇAN, Rudolf [5 %] - ŠTRKOLCOVÁ, Gabriela [5 %]. Thymol in fattening rabbit diet, its bioavailability and effects on intestinal morphology, microbiota from caecal content and immunity. In Journal of Animal Physiology and Animal Nutrition. ISSN 0931-2439, 2022, vol. 106, no. 2, p. 368-377. (2021: 2.718 - IF, 2.747 - IF 5y, 58 - H-index, 0.592 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q). Dostupné na internete: .
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://onlinelibrary.wiley.com/doi/10.1111/jpn.13595
OCA14. Characteristics of the author's contribution	co-author; the bearer of ideas in the article
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	The study investigated the effects of prolonged thymol supplementation on gut health and immune response in rabbits, focusing on its bioavailability in the organism. A total of 48 rabbits were divided into two groups: a control group and a group receiving thymol (0.025%) for 21 days, followed by a 7-day withdrawal period. During and after supplementation, thymol concentrations in feces and cecal content were significantly higher than in plasma. Thymol showed a clear positive impact on gut health (increased villus height to crypt depth ratio in the small intestine) and immune function (enhanced phagocytic activity and increased levels of lactic acid bacteria), with effects persisting even after withdrawal. The results confirm the biological activity of thymol at this concentration and its potential to improve rabbit health.
Other data
OCA16. Annotation of the output in English	Dietary thymol supplementation did not enhance growth performance in rabbits, but it was effectively absorbed from the intestine and remained detectable in feces even after withdrawal, likely due to caecotrophy and thymol biotransformation. Its sufficient bioavailability positively influenced gut morphology, as shown by an improved villus height to crypt depth ratio and beneficial effects on enterocytes. Thymol at the given concentration stimulated immune responses, including increased IgA production in the intestinal wall and elevated phagocytic cell activity in peripheral blood, and also showed anticoccidial activity. Although it did not reduce pathogenic bacteria, thymol increased the number of beneficial lactic acid bacteria (LAB) in the caecal appendix. Given the limited understanding of thymol metabolism in rabbits, further studies are needed to clarify its concentration–effect relationship and to determine optimal conditions for its use in animal production.
OCA17. List of maximum 5 most significant citations corresponding to the output	Chlorogenic acid improves growth performance of weaned rabbits via modulating the intestinal epithelium functions and intestinal microbiota / Chen, Jiali (Autor) (14.286%) ; Song, Zhicheng (Autor) (14.286%) ; Ji, Rongmei (Autor) (14.286%) ; Liu, Yongxu (Autor) (14.286%) ; Zhao, Hong (Autor) (14.285%) ; Liu, Lei (Autor) (14.285%) ; Li, Fuchang (Autor) (14.286%). – DOI 10.3389/fmicb.2022.1027101. – WOS CC. In: Frontiers in microbiology [elektronický dokument] . – Lausanne (Švajčiarsko) : Frontiers Media. – ISSN (online) 1664-302X. – Roč. 13 (2022). The effect of thymol on acetylcholine-induced contractions of the rat ileum and uterus under ex vivo conditions / Premrov Bajuk, Blanka [Autor, 20%] ; Prem, Luka [Autor, 20%] ; Vake, Tilen [Autor, 20%] ; Znidarsic, Neza [Autor, 20%] ; Snoj, Tomaz [Autor, 20%]. – DOI 10.3389/fphar.2022.990654. – WOS CC. In: Frontiers in Pharmacology [elektronický dokument] . – Lausanne (Švajčiarsko) : Frontiers Media. – ISSN (online) 1663-9812. – Roč. 13 (2022). Thymol improves the growth performance of blue foxes by regulating the gut microbiota / Yuan, Chongshan (Autor) (14.286%) ; Chen, Siqi (Autor) (14.286%) ; Sun, Rui (Autor) (14.286%) ; Ren, Lili (Autor) (14.286%) ; Zhao, Tiancheng (Autor) (14.285%) ; Wu, Min (Autor) (14.285%) ; Zhang, Aiwu (Autor) (14.286%). – DOI 10.3389/fmicb.2024.1368293. – WOS CC. In: Frontiers in microbiology [elektronický dokument] . – Lausanne (Švajčiarsko) : Frontiers Media. – ISSN (online) 1664-302X. – Roč. 15 (2024), s. [online] Effect of rearing system (free-range vs cage) on gut and muscle histomorphology and microbial loads of Italian White breed rabbits / Losacco, Caterina (Autor) (10%) ; Tinelli, Antonella (Autor) (10%) ; Dambrosio, Angela (Autor) (10%) ; Quaglia, Nicoletta C. (Autor) (10%) ; Passantino, Letizia (Autor) (10%) ; Schiavitto, Michele (Autor) (10%) ; Passantino, Giuseppe (Autor) (10%) ; Laudadio, Vito (Autor) (10%) ; Zizzo, Nicola (Autor) (10%) ; Tufarelli, Vincenzo (Autor) (10%). – DOI 10.5713/ab.23.0203. – WOS CC. In: Animal bioscience [textový dokument (print)] [elektronický dokument] . – Kórejská republika : Asian-Australasian Association of Animal Production Societies. – ISSN 2765-0189. – ISSN (online) 2765-0235. – Roč. 37, č. 1 (2024), s. 151-160 [tlačená forma] [online] Oregano Essential Oil in Livestock and Veterinary Medicine / Cui, Huan (Autor) (10%) ; Zhang, Cheng (Autor) (10%) ; Su, Kai (Autor) (10%) ; Fan, Tingli (Autor) (10%) ; Chen, Ligong (Autor) (10%) ; Yang, Zitong (Autor) (10%) ; Zhang, Mingda (Autor) (10%) ; Li, Jiaqi (Autor) (10%) ; Zhang, Yuxin (Autor) (10%) ; Liu, Juxiang (Autor) (10%). – DOI 10.3390/ani14111532. – WOS CC. In: Animals [elektronický dokument] . – Bazilej (Švajčiarsko) : Molecular Diversity Preservation International. – ISSN (online) 2076-2615. – Roč. 14, č. 11 (2024), s. [online]
OCA18. Characteristics of the output's impact on socio-economic practice	The results of the study suggest that thymol has the potential to be used as a natural alternative to chemical drugs and growth promoters in rabbit farming, which may have a positive impact on socio-economic practice. Its beneficial effects on gut health, immune response, and intestinal microbiota composition—without adverse side effects—represent a promising contribution to sustainable and environmentally friendly animal production. The use of thymol could lead to a reduction in the use of antibiotics and antiparasitic drugs (e.g., against coccidia), thereby lowering the risk of antimicrobial resistance and increasing the safety of animal products for consumers. This brings economic benefits in the form of reduced veterinary costs, as well as social benefits through the protection of public health. Moreover, this research supports the development of natural feed additives in agriculture and may stimulate demand for herbal products and their production, creating new opportunities for the agri-food sector and rural economies. However, further research is needed to optimize dosage, understand thymol metabolism, and evaluate its long-term effects on animals for broader application in practice.
OCA19. Characteristics of the output and related activities' impact on the educational process	The results of this study contribute to the deepening of knowledge in the fields of animal nutrition, digestive tract physiology, and livestock immunology, thereby enriching the educational process. These findings help students better understand the principles of alternative approaches to animal health, the importance of plant-derived bioactive compounds in feed, and the relevance of sustainable solutions in animal production. The study also highlights the need for an interdisciplinary approach, motivating students to engage in research projects that integrate biology, parasitology, and immunology.