MUDROŇOVÁ, Dagmar - KARAFFOVÁ, Viera - SEMJON, Boris - NAĎ, Pavel - KOŠČOVÁ, Jana - BARTKOVSKÝ, Martin - MAKIŠ, Andrej - BUJŇÁK, Lukáš - NAGY, Jozef - MOJŽIŠOVÁ, Jana - MARCINČÁK, Slavomír. Effects of dietary supplementation of humic substances on production parameters, immune status and gut microbiota of laying hens. In Agriculture. ISSN 2077-0472, 2021, vol. 11, no. 8, art. no. 744,p. 1-14

Basic data
OCA1. Surname awarded to the assessed personMojžišová Vaščinec
OCA2. Name awarded to the assessed personJana
OCA3. Degrees awarded to the assessed personDr. h. c. Prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staffhttps://www.portalvs.sk/regzam/detail/6013
OCA5. Area of assessmenthabilitation and inauguration procedure – general veterinary medicine
OCA6. Category of the research/artistic/other outputscientific output
OCA7. Year of publication of the research/artistic/other output2021
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)ID: 414994
OCA9. Hyperlink to the record in CRPA or CRAAhttps://app.crepc.sk/?fn=detailBiblioForm&sid=BD8873FEBC965481A59310BA7E
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputshttps://arl4.library.sk/arl-uvlk/sk/detail-uvlk_un_cat-0037998-Effects-of-dietary-supplementation-of-humic-substances-on-production-parameters-immune-status-and-g/?disprec=1&iset=4
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputsMUDROŇOVÁ, Dagmar - KARAFFOVÁ, Viera - SEMJON, Boris - NAĎ, Pavel - KOŠČOVÁ, Jana - BARTKOVSKÝ, Martin - MAKIŠ, Andrej - BUJŇÁK, Lukáš - NAGY, Jozef - MOJŽIŠOVÁ, Jana - MARCINČÁK, Slavomír. Effects of dietary supplementation of humic substances on production parameters, immune status and gut microbiota of laying hens. In Agriculture. ISSN 2077-0472, 2021, vol. 11, no. 8, art. no. 744,p. 1-14
OCA12. Type of the output (if the output is not registered in CRPA or CRAA) article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)https://www.mdpi.com/2077-0472/11/8/744
OCA14. Characteristics of the author's contributionThe author is the co- owner of the conceptual plan of the publication, she participated in the intrepretation of the results and in the final form of the publication.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.In this study, the influence of 0.5% HS supplementation on the specific production parameters of eggshell mineral quality, immune parameters (relative expression of IgA, IGF-2, MUC-2 gene in cecum; activity of phagocytes, percentage of selected lymphocyte subpopulations in the peripheral blood), and number of lactic acid bacteria and enterobacteria in the intestinal contents in laying hens was tested. The addition of 0.5% HS to the laying hen feed had a positive effect on egg laying rate, daily egg mass, egg weight, feed conversion and eggshell quality and also had an immunostimulatory effect manifested by increased phagocyte activity and B cell response. Concurrently, an increase in the number of enterobacteria in the intestinal contents and a decrease in the proportion of T lymphocytes (p < 0.05) was observed, which can be considered as a negative effect of HS. The results confirmed that HS can be used for the improvement of egg production and targeted immunostimulation, but their effect on the intestinal microbiota and T lymphocytes should be studied in more detail.
Other data
OCA16. Annotation of the output in EnglishThe addition of 0.5% HS to laying hen feed had a positive effect on laying rate, daily egg mass, egg weight, feed conversion, and eggshell quality and also had an immunostimulatory effect manifested by the increasing activity of the phagocytes and the B cell immune response. On the other hand, there was an observed increase in the number of enterobacteria in the intestinal contents, and the proportion of T lymphocytes in the blood was significantly reduced. The presented results confirm that HS can be used for the improvement of egg production and quality and for activation of phagocytosis and specific antibody immunity, but their influence on the intestinal microbiota will need to be further studied with respect to a wider range of microbial species inhabiting the digestive tract of laying hens.
OCA17. List of maximum 5 most significant citations corresponding to the output1. Marcinčák, S.; Semjon, B.; Marcinčáková, D.; Reitznerová, A.; Mudroňová, D.; Vašková, J.; Nagy, J. Humic Substances as a Feed Supplement and the Benefits of Produced Chicken Meat. Life 2023, 13, 927. https://doi.org/10.3390/life13040927 2. Humic acids alleviate dextran sulfate sodium-induced colitis by positively modulating gut microbiota / Huang, Jiazhang; Xu, Pengfei ; Shao, Mingzhi ; Wei, Bi; Zhang, Cong ; Zhang, Jie . – DOI 10.3389/fmicb.2023.1147110. – WOS CC. In: Frontiers in microbiology [elektronický dokument] . – Lausanne (Švajčiarsko) : Frontiers Media. – ISSN (online) 1664-302X. – Roč. 14 (2023), s. [online]; 3.Influence of Probiotics on Broiler Hens\' Intestinal Micro Biotas: A Meta-Analysis / Jain, Garima [Autor, 33.333%] ; Adlin Jebakumari, S. ; Agarwal, Trapty . – SCO. In: Revista Electronica de Veterinaria. – ISSN (online) 16957504. – Roč. 24, č. 3 (2023), s. 149-160; 4. A pH-triggered self-releasing humic acid hydrogel loaded with porcine interferon ?/? achieves anti-pseudorabies virus effects by oral administration / Sun, Maoyuan ; Shi, Yongli ; Lei, Baishi ; Zhang, Wuchao ; Feng, Jingjing ; Ge, Shenghu; Yuan, Wanzhe ; Zhao, Kuan . – DOI 10.1186/s13567-024-01411-w. – WOS CC. In: Veterinary research [textový dokument (print)] [elektronický dokument] . – London (Veľká Británia) : Springer Nature. BioMed Central. – ISSN 0928-4249. – ISSN (online) 1297-9716. – Roč. 55, č. 1 (2024), s. [tlačená forma] [online]
OCA18. Characteristics of the output's impact on socio-economic practiceThe results of this work confirmed that humic substances can be used for the improvement of egg production and targeted immunostimulation in laying hens production.
OCA19. Characteristics of the output and related activities' impact on the educational processThe knowledge gained from this work will be presented in the teaching process of the Immunology course.

Last updated: 28.10.2026

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