| Basic data |
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| OCA1. Surname awarded to the assessed person | Mojžišová Vaščinec |
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| OCA2. Name awarded to the assessed person | Jana |
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| OCA3. Degrees awarded to the assessed person | Dr. h. c. Prof. , DVM, PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6013 |
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| OCA5. Area of assessment | habilitation and inauguration procedure – general veterinary medicine |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2024 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | ID: 1253357 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=9A77F24CB1252B04C2D3530220F3 |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://arl4.library.sk/arl-uvlk/sk/detail-uvlk_un_cat-0044547-The-first-evidence-of-Asianlike-CPV2b-in-Slovakia-in-a-vaccinated-dog-with-an-acute-fatal-course-o/?disprec=1&iset=6 |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | PELEGRINOVÁ, Andrea - PETROUŠKOVÁ, Patrícia - KORYTÁR, Ľuboš - ONDREJKOVÁ, Anna - DRÁŽOVSKÁ, Monika - VOJTEK, Boris - MOJŽIŠOVÁ, Jana - PROKEŠ, Marián - KOSTIČÁK, Maroš - ZÁKUTNÁ, Ľubica - DOLNÍK, Michal - MANDELÍK, René. The first evidence of Asian-like CPV-2b in Slovakia in a vaccinated dog with an acute fatal course of parvovirus infection: a case report. In: Veterinary Research Communications. 2024. ISSN 0165-7380, DOI : 10.1007/s11259-024-10492-z (2024), p. [1-10]
(2022: 2.200 - IF, 60 - H-index, 2.300 - IF 5y, 0.526 - SJR, Q1 - SJR Best Q, Q2 - JCR Best Q) |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://link.springer.com/article/10.1007/s11259-024-10492-z |
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| OCA14. Characteristics of the author's contribution | The author is the co-owner of the conceptual plan of the publication, she participated in the experimental part, the intrepretation of the results and in the final form of the publication. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | This study provides a comprehensive description of the clinical course of a fatal parvovirus infection in a 33 vaccinated dachshund puppy, along with the first identification of a new CPV-2 variant in Slovakia, elucidated
34 through molecular amino acid analysis of the VP2 gene. Clinical symptoms included apathy, vomiting, and bloody 35 diarrhea. Despite rapid diagnosis and initiation of intensive therapy, the dog succumbed within 48 hours of 36 admission to the University Veterinary Hospital. A fecal sample was examined. The coding sequence of the CPV37 2b strain (VP2 426Asp) was obtained. The substitution on residue 297 of the VP2 protein (Ser to Ala) is used as a 38 genomic marker for the so-called \"new CPV-2a/2b\" variants, and currently, it predominates among the strains
39 circulating in dogs. The virus detected in the patient was related to strains of CPV-2c of Asian origin and unrelated 40 to European CPV-2b strains. The sequence had genetic signatures typical of Asian strains (VP2: 5Gly, 267Tyr, 41 324Ile, 370Arg, and 440Thr). Phylogenetic analysis classified this strain as similar to Asian strains of CPV-2c. It
42 is believed to be derived from an Asian strain similar to CPV-2c that acquired the 426Asp mutation. With this 43 finding, we present the first evidence of an Asian CPV-2b strain in the territory of Slovakia |
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| Other data |
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| OCA16. Annotation of the output in English | Detection of the CPV-2 strain confirms the first evidence of an Asian strain of CPV-2b associated with Asian strains similar to CPV-2c on the territory of Slovakia, which does not correspond to European strains. Rectal swab from an animal that died within 48 hours of an acute course of parvovirosis with overall organ failure following
previous vaccination was used for diagnosis. In conclusion, the Slovakia/Kosice/47/2022 isolate identified in this study is antigenically classified as CPV-2b, but phylogenetically is a part of the Asian CPV-2c clade with which it shared several mutations in VP2 capsid protein. Considering the mentioned factors, these mutations may have an impact on the effectiveness of current vaccines and the virus\'sability to evade the canine immune system. This could also lead to the potential inadequate immune response and explain why, despite being vaccinated, a puppy from this study succumbed to the parvovirus infection in a short time. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | Safwat MS, Khodeir MH, Etman RH. Canine parvovirus type 2 infection in vaccinated puppies: role of vaccination practices and viral antigenic variation. BMC Vet Res. 2026 Mar 26;22(1):214. doi: 10.1186/s12917-026-05403-0. PMID: 41888840; PMCID: PMC13063580. |
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| OCA18. Characteristics of the output's impact on socio-economic practice | Evidence of circulation of an Asian strain of canine parvovirus has practical implications for veterinary practice in terms of diagnosis and prevention of canine parvovirus |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | The scientific outputs are applicable to the teaching of the course Infectious Diseases II |
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