ADC Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis. Tóthová, Csilla Karasová, Martina Blaňarová, Lucia Fialkovičová, Mária Nagy, Oskar. In Scientific Reports 2020, Roč. 10, č. 3, Art. no. 18904, s. 1-9

Basic data
OCA1. Surname awarded to the assessed person	Nagy
OCA2. Name awarded to the assessed person	Oskar
OCA3. Degrees awarded to the assessed person	Prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6036
OCA5. Area of assessment	habilitation and inauguration procedure – general veterinary medicine
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2020
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	217092
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioFormChildA4M9R&sid=5779C83C492E236D6195EF2A9D&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.webofscience.com/wos/woscc/full-record/WOS:000587347400026
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis. Tóthová, Csilla Karasová, Martina Blaňarová, Lucia Fialkovičová, Mária Nagy, Oskar. In Scientific Reports 2020, Roč. 10, č. 3, Art. no. 18904, s. 1-9
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.nature.com/articles/s41598-020-75908-7
OCA14. Characteristics of the author's contribution	The author is the bearer of the main ideas and co-creator of the output.At the same time, he is also the beneficiary of part of the funding of the projects from which the output has been realised.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	The results indicate that the serum protein electrophoretic pattern in dogs are significantly altered both by B. gibsoni and B. canis infections, with different nature and magnitude of changes in the infected dogs according to the species of Babesia parasite involved in the infection. The obtained results suggest marked differences in the response of the organism to the infection caused by different Babesia parasites. When compared to infections with B. canis, characteristic alterations in the serum protein associated with B. gibsoni infection in dogs include significantly higher total serum proteins and γ-globulins, while the relative concentrations of albumin and A/G ratio are markedly significantly lower. The results also suggest some differences when comparing the results of a group of dogs with B. gibsoni infection and evaluated forms of B. canis disease. Identification of those protein fractions whose serum concentrations undergo marked changes due to the infection with B. gibsoni may provide useful information for the understanding of metabolic and pathological processes occurring in the infected animals. Due to the increasing frequency of infections also in Europe, this study may be the first step towards further investigations of biochemical and metabolic changes in dogs infected with B. gibsoni.
Other data
OCA16. Annotation of the output in English	Canine babesiosis may cause several hematological and biochemical changes, but only limited studies are available regarding the possible differences of changes in animals infected by different Babesia parasites. The study focused on the evaluation of the differences in serum protein electrophoretic pattern between dogs naturally infected with B. gibsoni (17 dogs) and B. canis (40 dogs). The mean values of total proteins, beta(1)-, beta(2)- and gamma-globulins were in dogs infected with B. gibsoni significantly higher (P < 0.05 and P < 0.001) than in dogs infected with B. canis. The relative concentrations of albumin, alpha(1)-, alpha(2)-globulins and the A/G ratios were in the B. gibsoni infected dogs significantly lower (P < 0.001), no significant differences were found in the relative concentrations of beta(1)- and beta(2)-globulins. Significant differences were found in most of the evaluated parameters when comparing the results in relation to the form of B. canis infection to B. gibsoni infection. Hematological indices showed significant differences between dogs infected with B. gibsoni and the complicated form of B. canis infection. In conclusion, the obtained results suggest differences in the changes of serum protein electrophoretic pattern between dogs infected with both Babesia species and thus, in the response to the infection caused by various Babesia parasites.
OCA17. List of maximum 5 most significant citations corresponding to the output	[1] ASAWAKARN, Sariya - TAWEETHAVONSAWAT, Piyanan. Characterization of serum protein electrophoresis patterns and C-reactive protein in canine tick-borne diseases. In VETERINARY WORLD. ISSN 0972-8988, 2021, vol. 14, no. 8, pp. 2150-2154., Registrované v: WoS [1]/[1] ASAWAKARN, Sariya - DHITAVAT, Sirakarnt - TAWEETHAVONSAWAT, Piyanan. Evaluation of the hematological and serum protein profiles of blood parasite coinfection in naturally infected dogs. In THAI JOURNAL OF VETERINARY MEDICINE. ISSN 0125-6491, 2021, vol. 51, no. 4, pp. 723-728. Dostupné na: https://doi.org/10.14456/tjvm.2021.87., Registrované v: WOS [1]/[1] TEODOROWSKI, Oliwier - KALINOWSKI, Marcin - WINIARCZYK, Dagmara - DOKUZEYLUL, Banu - WINIARCZYK, Stanislaw - ADASZEK, Lukasz. Babesia gibsoni Infection in Dogs-A European Perspective. In ANIMALS, 2022, vol. 12, no. 6, pp. ISSN 2076-2615. Dostupné na: https://doi.org/10.3390/ani12060730., Registrované v: WOS [1]/[1] HA, Yan - MENG, Xiangjie - DU, Zeyu - TIAN, Junfeng - YUAN, Yu. Semi-supervised graph learning framework for apicomplexan parasite classification. In Biomedical Signal Processing and Control, 2023-03-01, 81, pp. ISSN 17468094. Dostupné na: https://doi.org/10.1016/j.bspc.2022.104502., Registrované v: SCOPUS [1]/[1] JORNET-RIUS, Oriol - CHORNARM, Nida - SKELDON, Niki - MCGREW, Ashley - LAPPIN, Michael - SOLANO-GALLEGO, Laia - MOORE, A. Russell. Evaluation of serum protein electrophoresis and immunofixation in dogs seropositive for various vector-borne pathogens. In Veterinary Clinical Pathology, 2024-12-01, 53, 4, pp. 420-430. ISSN 02756382. Dostupné na: https://doi.org/10.1111/vcp.13399., Registrované v: SCOPUS
OCA18. Characteristics of the output's impact on socio-economic practice	Babesiosis is one of the most important globally extended infections of dogs. Infections caused with B. canis are more common, but recently, due to global climate changes, B. gibsoni has been recognized as an important pathogen that affects dogs also in Middle Europe. Cases have been reported in Germany, Croatia, as well as from Serbia and Poland. The infection with B. gibsoni mostly causes mild clinical signs which are manifested as a subclinical infection or associated only with weight loss and weakness. Furthermore, chronic infections may be also observed that usually are completely asymptomatic or may be characterized by intermittent fever, lethargy, and weight loss. In some cases, after initial parasitemia, the immune system may not totally eradicate the infection, and a chronic carrier state remains without clinical signs of the disease. Relapses may occur months to years later and many complications may develop, including glomerulonephritis and polyarthritis.
OCA19. Characteristics of the output and related activities' impact on the educational process	The obtained results expand the knowledge in the field of education in the diagnosis, prevention and therapy of disorders of animals.