ADC51 KARASOVÁ, Martina - TÓTHOVÁ, Csilla - VÍCHOVÁ, Bronislava - BLAŇAROVÁ, Lucia - KISKOVÁ, Terézia - GRELOVÁ, Simona - STAROŇOVÁ, Radka - MICHÁĽOVÁ, Alena - KOŽÁR, Martin - NAGY, Oskar - FIALKOVIČOVÁ, Mária. Clinical efficacy and safety of Malarone®, Azithromycin and Artesunate combination for treatment of Babesia gibsoni in naturally infected dogs. In Animals. ISSN 2076-2615, 2022, vol. 12, no. 6, art. no. 708, p. [1-12]. (2022

ADC51 KARASOVÁ, Martina - TÓTHOVÁ, Csilla - VÍCHOVÁ, Bronislava - BLAŇAROVÁ, Lucia - KISKOVÁ, Terézia - GRELOVÁ, Simona - STAROŇOVÁ, Radka - MICHÁĽOVÁ, Alena - KOŽÁR, Martin - NAGY, Oskar - FIALKOVIČOVÁ, Mária. Clinical efficacy and safety of Malarone®, Azithromycin and Artesunate combination for treatment of Babesia gibsoni in naturally infected dogs. In Animals. ISSN 2076-2615, 2022, vol. 12, no. 6, art. no. 708, p. [1-12]. (2022 - Current Contents).

Basic data
OCA1. Surname awarded to the assessed person	Nagy
OCA2. Name awarded to the assessed person	Oskar
OCA3. Degrees awarded to the assessed person	Prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6036
OCA5. Area of assessment	habilitation and inauguration procedure – general veterinary medicine
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2022
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	468562
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=234FD712864E2777B19E842872
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://pubmed.ncbi.nlm.nih.gov/35327106/
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ADC51 KARASOVÁ, Martina - TÓTHOVÁ, Csilla - VÍCHOVÁ, Bronislava - BLAŇAROVÁ, Lucia - KISKOVÁ, Terézia - GRELOVÁ, Simona - STAROŇOVÁ, Radka - MICHÁĽOVÁ, Alena - KOŽÁR, Martin - NAGY, Oskar - FIALKOVIČOVÁ, Mária. Clinical efficacy and safety of Malarone®, Azithromycin and Artesunate combination for treatment of Babesia gibsoni in naturally infected dogs. In Animals. ISSN 2076-2615, 2022, vol. 12, no. 6, art. no. 708, p. [1-12]. (2022 - Current Contents).
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://doi.org/10.3390/ani12060708
OCA14. Characteristics of the author's contribution	The author is the bearer of the main ideas and co-creator of the output.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	Babesia gibsoni is a tick-borne protozoal blood parasite that may cause hemolytic anemia, thrombocytopenia, lethargy, and/or splenomegaly in dogs. Many drugs have been used in management of canine babesiosis such as monotherapy or combined treatment, including diminazene aceturate, imidocarb dipropionate, atovaquone, and antibiotics. This report examines the effectiveness and safety of Malarone®, azithromycin (AZM) and artesunate (ART) combination for the treatment of babesiosis in dogs naturally infected with Babesia gibsoni. Twelve American Pit Bull Terriers were included in the experiment. Examined dogs underwent clinical and laboratory analysis including hematology and biochemistry profile and serum protein electrophoresis. After diagnosis, the dogs received combined therapy with Malarone®, azithromycin and artesunate for 10 days. The combined treatment improved hematology and biochemical parameters to the reference range gradually during the first 14 days already, resulting in the stable values until day 56 after treatment. No clinically apparent adverse effects were reported during treatment and monitoring. No relapses of parasitemia were detected in control days 180, 360, 540 and 720 in all dogs. Results of the study indicate that the combined treatment leads to successful elimination of parasitemia in chronically infected dogs with B. gibsoni.
Other data
OCA16. Annotation of the output in English	Babesia gibsoni is a tick-borne protozoal blood parasite that may cause hemolytic anemia, thrombocytopenia, lethargy, and/or splenomegaly in dogs. Many drugs have been used in management of canine babesiosis such as monotherapy or combined treatment, including diminazene aceturate, imidocarb dipropionate, atovaquone, and antibiotics. This report examines the effectiveness and safety of Malarone®, azithromycin (AZM) and artesunate (ART) combination for the treatment of babesiosis in dogs naturally infected with Babesia gibsoni. Twelve American Pit Bull Terriers were included in the experiment. Examined dogs underwent clinical and laboratory analysis including hematology and biochemistry profile and serum protein electrophoresis. After diagnosis, the dogs received combined therapy with Malarone®, azithromycin and artesunate for 10 days. The combined treatment improved hematology and biochemical parameters to the reference range gradually during the first 14 days already, resulting in the stable values until day 56 after treatment. No clinically apparent adverse effects were reported during treatment and monitoring. No relapses of parasitemia were detected in control days 180, 360, 540 and 720 in all dogs. Results of the study indicate that the combined treatment leads to successful elimination of parasitemia in chronically infected dogs with B. gibsoni.
OCA17. List of maximum 5 most significant citations corresponding to the output	[1]/[1] BRAVO-RAMOS, José Luis - SÁNCHEZ-MONTES, Sokani - BALLADOS-GONZÁLEZ, Gerardo Gabriel - ROMERO-SALAS, Dora - GAMBOA-PRIETO, Jannete - OLIVARES-MUÑOZ, Angélica. An atypical case of Babesia bigemina parasitising a dog from a rural area of eastern Mexico. In Revista Brasileira de Parasitologia Veterinaria, 2022-01-01, 31, 3, pp. ISSN 0103846X. Dostupné na: https://doi.org/10.1590/S1984-29612022039., Registrované v: SCOPUS [1]/[1] DEAR, Jonathan D. - BIRKENHEUER, Adam. Babesia in North America: An Update. In Veterinary Clinics of North America Small Animal Practice, 2022-11-01, 52, 6, pp. 1193-1209. ISSN 01955616. Dostupné na: https://doi.org/10.1016/j.cvsm.2022.07.016., Registrované v: SCOPUS [1]/[1] GOMES, A.C. - DE JESUS, J.V. - SILVA, L.M.S. - OLIVEIRA, M.R. - LIMA, V.F.S. DIAGNÓSTICO E TRATAMENTO DA BABESIOSE NA FASE AGUDA EM UM CAO DOMICILIADO FEBRIL DO ALTO SERTAO SERGIPANO – RELATO DE CASO. In ENCICLOPÉDIA BIOSFERA, Centro Científico Conhecer. ISSN 1809-0583, 2023, vol. 20, no. 44, p. 136-146. CASO, Registrované v: WOS [1]/[1] PANICKER, Varuna Purushothama - NARAYANAN, Athira - SREEDHARAN NAIR, Ajith Kumar - KRISHNAN, Anjaly - AJAY, Nimna - KUMAR, Vinod. Standardization of quantitative PCR (qPCR) method to detect the level of parasitaemia in Babesia gibsoni infected dogs. In Journal of Microbiological Methods, 2024-09-01, 224, pp. ISSN 01677012. Dostupné na: https://doi.org/10.1016/j.mimet.2024.107009., Registrované v: WOS, SCOPUS [1]/[1] MA, Rui - YUE, Chanjuan - GU, Jiang - WU, Wei - HOU, Rong - HUANG, Wenjun - LI, Bi - XUE, Fei - HUANG, Chong - BI, Wenlei - LIU, Jiabin - YU, Xiang - LI, Zusheng - YANG, Wanjing - FU, Mingxia - YANG, Hong - QI, Dunwu. Efficacy of azithromycin combined with compounded atovaquone in treating babesiosis in giant pandas. In Parasites and Vectors, 2024-12-01, 17, 1, pp. Dostupné na: https://doi.org/10.1186/s13071-024-06615-9., Registrované v: SCOPUS
OCA18. Characteristics of the output's impact on socio-economic practice	Babesia gibsoni is an intracellular parasite of red blood cells that may cause anemia in dogs. Many drugs have been used in management of canine babesiosis such as monotherapy or combined treatment, but complete elimination of parasitemia was not proven, frequent relapses were observed and adverse effects occurred during treatment. This report examines the effectiveness and safety of Malarone®, azithromycin (AZM) and artesunate (ART) combination for the treatment of babesiosis in dogs naturally infected with Babesia gibsoni. The treatment improved hematology and biochemical parameters to the reference range. No clinically apparent adverse effects were reported during treatment and monitoring and no relapses of parasitemia were detected during monitoring until day 720 after treatment. Results of the study indicate that the combined treatment leads to successful elimination of parasitemia in chronically infected dogs with B. gibsoni.
OCA19. Characteristics of the output and related activities' impact on the educational process	The obtained results expand the knowledge in the field of education in the diagnosis, prevention and therapy of disorders of animals.