Ameliorative effect of biosynthesized titanium dioxide nanoparticles using garlic extract on the body weight and developmental toxicity of liver in albino rats compared with chemically synthesized nanoparticles / Kamal, Zeinab; Ebnalwaled, Alaa A.; Al-Amgad, Zeinab; Said, Alaa H.; Metwally, Asmaa A.; Zigo, František; Ondrašovičová, Silvia; Rehan, Ibrahim F. [recenzované]. – DOI 10.3389/fvets.2022.1049817. – SCO ; CCC ; WOS CC. In: Frontiers in veterinary science [elektronický dokument] . – Lausanne (Švajčiarsko) : Frontiers Media. – ISSN (online) 2297-1769. – č. 9 (2022), art.no. 1049817, s. [1-16] [online]

Basic data
OCA1. Surname awarded to the assessed person	Zigo
OCA2. Name awarded to the assessed person	František
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/20442
OCA5. Area of assessment	habilitation and inauguration procedure – general veterinary medicine
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2022
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	ID: 1005496
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=7CB117824CF3FE33DCC78AE386BD
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	Ameliorative effect of biosynthesized titanium dioxide nanoparticles using garlic extract on the body weight and developmental toxicity of liver in albino rats compared with chemically synthesized nanoparticles / Kamal, Zeinab; Ebnalwaled, Alaa A.; Al-Amgad, Zeinab; Said, Alaa H.; Metwally, Asmaa A.; Zigo, František; Ondrašovičová, Silvia; Rehan, Ibrahim F. [recenzované]. – DOI 10.3389/fvets.2022.1049817. – SCO ; CCC ; WOS CC. In: Frontiers in veterinary science [elektronický dokument] . – Lausanne (Švajčiarsko) : Frontiers Media. – ISSN (online) 2297-1769. – č. 9 (2022), art.no. 1049817, s. [1-16] [online]
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://doi.org/10.3389/fvets.2022.1049817
OCA14. Characteristics of the author's contribution	Concept, Formal analysis, Funding acquisition, Investigation, Methodology, Writing—original draft
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	The application of metallic nanoparticles poses risks to human and animal health. Titanium dioxide nanoparticles (TiO2NPs) are the most commonly synthesized metallic oxides in the world. Exposure to TiO2NPs can cause toxicity in the target organisms. This study aimed to evaluate the effects of green and chemical TiO2NPs on maternal and embryo-fetal livers. Green TiO2NPs using garlic extract (GTiO2NPs) and chemical TiO2NPs (CHTiO2NPs) were synthesized and characterized by X-ray powder diffraction and high-resolution transmission electron microscopy. The biosynthesis of TiO2NPs using garlic extract had a minimal effect on the normal architecture of the liver. It could be concluded that the bioactivity of TiO2NPs can be modified by green synthesis using garlic extract. Compared to the CHTiO2NPs, exposure to GTiO2NPs showed reduced liver damage in maternal and embryo-fetal rats.
OCA17. List of maximum 5 most significant citations corresponding to the output	l-Harbi L.M., Ezzeldien M., Elhenawy A.A., Said A.H. Assessment of the bioactivity of bioinspired magnesium oxide nanoparticles from the Azadirachta indica extract. (2024) Frontiers in Bioengineering and Biotechnology, 12, art. no. 1480694, DOI: 10.3389/fbioe.2024.1480694 Alghamdi R.A., Al-Zahrani M.H., Altarjami L.R., Al Abdulmonem W., Samir N., Said A., Shami A.A., Mohamed W.S., Ezzeldien M. Biogenic Zinc oxide nanoparticles from Celosia argentea: toward improved antioxidant, antibacterial, and anticancer activities. (2023) Frontiers in Bioengineering and Biotechnology, 11, art. no. 1283898, DOI: 10.3389/fbioe.2023.1283898 Ahmed N.K., Abbady A., Elhassan Y.A., Said A.H. Green Synthesized Titanium Dioxide Nanoparticle from Aloe Vera Extract as a Promising Candidate for Radiosensitization Applications. (2023) BioNanoScience, 13 (2), pp. 730 - 743, DOI: 10.1007/s12668-023-01085-2 Kamal Z., Ebnalwaled A.A., Al-Amgad Z., Saied A.R.A., Metwally A.A., Said A.H. Immunomodulatory and antioxidant effect of green synthesized titanium dioxide nanoparticles on pregnant female albino rats and their fetuses. (2023) Environmental Science and Pollution Research, 30 (19), pp. 55455 - 55470, DOI: 10.1007/s11356-023-26264-2 Farrukh F., Mahnoor A.S., Anum G., Humera W. Neutralization of Naja naja venom by green and chemically synthesized titanium dioxide nanoparticles. (2025) Nano Express, 6, art. no. 015008, DOI: 10.1088/2632-959X/adb1fc
OCA18. Characteristics of the output's impact on socio-economic practice	The study\'s outcomes have significant socio-economic relevance, particularly in raising awareness of implementing nanotechnologies to benefit human and animal health. The study provides clear evidence that the \"green synthesis\" of titanium dioxide nanoparticles using garlic extract significantly reduces their toxicity. This is fundamental for developing safer, more environmentally friendly nanoapplications in medicine, pharmacy, the food industry, and cosmetics.
OCA19. Characteristics of the output and related activities' impact on the educational process	The study\'s outcomes provide an excellent multidisciplinary educational resource for students in the fields of veterinary medicine and natural substances (e.g., the use of plant extracts as eco-friendly alternatives in nanotechnology), toxicology and pharmacology (comparison of the effects of different forms of nanoparticles on the organism), as well as nanochemistry and technology, for a deeper understanding. Moreover, students can gain practical knowledge in experimental design, data processing, and understanding the biological implications of chemical and green nanotechnology on the health of both animals and humans.