Cingeľová Maruščáková, I.; Schusterová, P.; Popelka, P.; Gancarčíková, S.; Csank, T.; Fečkaninová, A.; Ratvaj, M.; Mudroňová, D. Effect of Autochthonous Lactobacilli on Immunologically Important Molecules of Rainbow Trout after Bacterial Infection Studied on Intestinal Primoculture. Fish and Shellfish Immunology 2021, 119, 379–383. https://doi.org/10.1016/j.fsi.2021.10.021.

Basic data
OCA1. Surname awarded to the assessed person	Csank
OCA2. Name awarded to the assessed person	Tomáš
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6133
OCA5. Area of assessment	habilitation and inauguration procedure – microbiology and immunology
OCA6. Category of the research/artistic/other output
OCA7. Year of publication of the research/artistic/other output	2021
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	431183
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioFormChildA962D&sid=117E8DF36B6BB49F0650DF69F7&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.scopus.com/pages/publications/85117698531
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	Cingeľová Maruščáková, I.; Schusterová, P.; Popelka, P.; Gancarčíková, S.; Csank, T.; Fečkaninová, A.; Ratvaj, M.; Mudroňová, D. Effect of Autochthonous Lactobacilli on Immunologically Important Molecules of Rainbow Trout after Bacterial Infection Studied on Intestinal Primoculture. Fish and Shellfish Immunology 2021, 119, 379–383. https://doi.org/10.1016/j.fsi.2021.10.021.
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.sciencedirect.com/science/article/pii/S1050464821003454?pes=vor&utm_source=scopus&getft_integrator=scopus
OCA14. Characteristics of the author's contribution	The author is researcher of all research in the field
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	Nowadays, the aquaculture industry is one of the fastest growing industries. Intensive aquaculture has a negative impact on fish health. Probiotic bacteria are often used due to beneficial effect to health of host, e.i. decrease of diseases outbreaks, immunomodulatory effect or better utilization of feed. The aim of this work was to study the influence of probiotic bacteria on the immune response of trout intestinal cells in primoculture infected with pathogenic bacteria.
OCA17. List of maximum 5 most significant citations corresponding to the output	1. Vasyliuk, O. M.; Skrotskyi, S. O.; Khomenko, L. A.; Babich, T. V. PROBIOTICS BASED ON LACTIC ACID BACTERIA FOR AQUACULTURE. Mikrobiolohichnyi Zhurnal 2023, 85 (2), 75–92. https://doi.org/10.15407/microbiolj85.02.075. 2. Fülöpová, N.; Chomová, N.; Elbl, J.; Mudroňová, D.; Sivulič, P.; Pavloková, S.; Franc, A. Preparation and Evaluation of a Dosage Form for Individualized Administration of Lyophilized Probiotics. Pharmaceutics 2023, 15 (3). https://doi.org/10.3390/pharmaceutics15030910 3. Liu, Z.-Y.; Yang, H.-L.; Wei, C.-Y.; Cai, G.-H.; Ye, J.-D.; Zhang, C.-X.; Sun, Y.-Z. Commensal Bacillus Siamensis LF4 Induces Antimicrobial Peptides Expression via TLRs and NLRs Signaling Pathways in Intestinal Epithelial Cells of Lateolabrax Maculatus. Fish and Shellfish Immunology 2023, 134. https://doi.org/10.1016/j.fsi.2023.108634 4. Chomová, N.; Pavloková, S.; Sondorová, M.; Mudroňová, D.; Fečkaninová, A.; Popelka, P.; Koščová, J.; Žitňan, R.; Franc, A. Development and Evaluation of a Fish Feed Mixture Containing the Probiotic Lactiplantibacillus Plantarum Prepared Using an Innovative Pellet Coating Method. Frontiers in Veterinary Science 2023, 10. https://doi.org/10.3389/fvets.2023.1196884. 5. Fülöpová, N.; Chomová, N.; Elbl, J.; Mudroňová, D.; Sivulič, P.; Pavloková, S.; Franc, A. Preparation and Evaluation of a Dosage Form for Individualized Administration of Lyophilized Probiotics. Pharmaceutics 2023, 15 (3). https://doi.org/10.3390/pharmaceutics15030910.
OCA18. Characteristics of the output's impact on socio-economic practice	In the experiment, we tested the effect of pre-treatment of intestinal cells with an autochthonous strain of Lactobacillus plantarum R2 Biocenol™ (CCM 8674) following infection with the most serious salmonid pathogens – Aeromonas salmonicida subsp. salmonicida (CCM 1307) and Yersinia ruckeri (CCM 6093). Tested probiotic strain reduced inflammation after A. salmonicida infection through decreased expression of pro-inflammatory cytokines and increased expression of anti-inflammatory cytokines. In contrast, after infection with Y. ruckeri, which causes immunosuppression, the probiotic strain stimulated immunity by up-regulation of expression of proinflammatory cytokines and suppressed the expression of anti-inflammatory cytokines. These results are a prerequisite for the immunomodulatory potential of the strain, but its action must be confirmed in subsequent in vivo experiments.
OCA19. Characteristics of the output and related activities' impact on the educational process	The obtained data and the used methods are implemented in the education of postgraduate students and in the education of veterinarians.