| Basic data |
|---|
| OCA1. Surname awarded to the assessed person | Hudák |
|---|
| OCA2. Name awarded to the assessed person | Alexander |
|---|
| OCA3. Degrees awarded to the assessed person | Assoc. prof. , M.A., PhD |
|---|
| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/15736 |
|---|
| OCA5. Area of assessment | study programme pharmacy (joint study programme) · I. + II. degree |
|---|
| OCA6. Category of the research/artistic/other output | scientific output |
|---|
| OCA7. Year of publication of the research/artistic/other output | 2021 |
|---|
| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | 429871 |
|---|
| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioFormChildC9OHE&sid=3FA563B72988EE5765E3BF1D97&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok |
|---|
| Characteristics of the output that is not registered in CRPA or CRAA |
|---|
| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://www.webofscience.com/wos/woscc/full-record/WOS:000706830500042?SID=EUW1ED0E37RjtW6795rOFOlrpNGoC |
|---|
| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | ADC ALMÁŠI, Miroslav - MATIAŠOVÁ, Anna Alexovič - ŠULEKOVÁ, Monika - BEŇOVÁ, Eva - ŠEVC, Juraj - VÁHOVSKÁ, Lucia - LISNICHUK, Maksym - GIRMAN, Vladimí - ZELEŇÁKOVÁ, Adriana - HUDÁK, Alexander - ZELEŇÁK, Vladimír. In vivo study of light-driven naproxen release from gated mesoporous silica drug delivery system. In Scientific Reports. ISSN 2045-2322, 2021, vol. 11, no. 1, art. no. 20191, p. [1-12]. (2020: 4.380 - IF, 5.134 - IF 5y, 213 - H-index, 1.240 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q) |
|---|
| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
|---|
| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.nature.com/articles/s41598-021-99678-y |
|---|
| OCA14. Characteristics of the author's contribution | |
|---|
| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | |
|---|
| Other data |
|---|
| OCA16. Annotation of the output in English | A drug delivery system based on mesoporous particles MCM-41 was post-synthetically modifed by photo-sensitive ligand, methyl-(2E)-3-(4-(triethoxysilyl)-propoxyphenyl)-2-propenoate (CA) and the pores of MCM-41 particles were loaded with Naproxen sodium salt (NAP). The CA was used as a photoactive molecule that can undergo a reversible photo-dimerization by [2π+ 2π] cycloaddition when irradiated with UV light of specifc wavelengths. Thus, it has a function of gatekeeper that is responsible for opening/closing the pores and minimizing premature release of NAP. The physicochemical properties of the prepared system were studied by infrared spectroscopy (IR), nitrogen adsorption measurements, thermogravimetric analysis (TGA), scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDX). The mechanism of the opening/closing pores was confrmed by UV measurements. In vitro and in vivo drug release experiments and the concentration of released NAP was determined by UV spectroscopy and highperformance liquid chromatography (HPLC). In vivo drug release in the blood circulatory system of rats has demonstrated the efective photo-cleavage reaction of CA molecules after UV-light stimulation. The localization and morphological changes of the particles were studied in the blood and liver of rats at diferent time intervals. The particles in the blood have been shown to retain their original rod-like shape, and the particles in the liver have been hydrolysed, which has resulted in spherical shape with a reduced size. |
|---|
| OCA17. List of maximum 5 most significant citations corresponding to the output | Elsheikh MA, El-Feky YA, Al-Sawahli MM, Ali ME, Fayez AM, Abbas H. A Brain-Targeted Approach to Ameliorate Memory Disorders in a Sporadic Alzheimer\'s Disease Mouse Model via Intranasal Luteolin-Loaded Nanobilosomes.. Pharmaceutics. 2022 Mar 5;14(3):576. doi: 10.3390/pharmaceutics14030576.PMID: 35335952
Wang M, Wang C, Ren S, Pan J, Wang Y, Shen Y, Zeng Z, Cui H, Zhao X. Versatile Oral Insulin Delivery Nanosystems: From Materials to Nanostructures. Int J Mol Sci. 2022 Mar 20;23(6):3362. doi: 10.3390/ijms23063362.PMID: 35328783
Nova-Fernandez, J.L., Garcia, M.J. (...), Aleman, J. Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles. Chemical Communications. 2022, 58 , 4611-4614. DOI https://doi.org/10.1039/D2CC01065H |
|---|
| OCA18. Characteristics of the output's impact on socio-economic practice | |
|---|
| OCA19. Characteristics of the output and related activities' impact on the educational process | |
|---|
