| Basic data |
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| OCA1. Surname awarded to the assessed person | Hudák |
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| OCA2. Name awarded to the assessed person | Alexander |
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| OCA3. Degrees awarded to the assessed person | Assoc. prof. , M.A., PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/15736 |
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| OCA5. Area of assessment | study programme pharmacy (joint study programme) · I. + II. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2020 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | 187887 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=CB4D57913478E3D229CED6734D |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://www.scopus.com/record/display.uri?eid=2-s2.0-85084317201&origin=inward&txGid=cc11fc2a108613fac2c8514195a841c8&featureToggles=FEATURE_NEW_DOC_DETAILS_EXPORT:1 |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | ADC Doxorobicin as cargo in a redox-responsive drug delivery system capped with water dispersible ZnS nanoparticles / Lukáš Žid, Vladimír Zeleňák, Vladimír Girman, Jozef Bednarčík, Adriana Zeleňáková, Jaroslava Szűcsová, Virginie Hornebecq, Alexander Hudák, Monika Šuleková, Lucia Váhovská. In RSC Advances. - ISSN 2046-2069. - Vol. 10, no. 27 (2020), p. 15825-15835. (2019: 3.119 - IF, 3.098 - IF 5y, 128 - H-index, 0.736 - SJR, Q1 - SJR Best Q, Q2 - JCR Best Q). |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://pubs.rsc.org/en/content/articlelanding/2020/ra/d0ra02091e#!divCitation |
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| OCA14. Characteristics of the author's contribution | I participated in the characterization of the studied materials. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | |
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| Other data |
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| OCA16. Annotation of the output in English | In this work, we have prepared and investigated a redox-responsive drug delivery system (DDS) based on a porous carrier. Doxorubicin (DOX), a chemotherapy medication for treatment of different kinds of cancer, was used as a model drug in the study. DOX was loaded in ordered hexagonal mesoporous silica SBA-15, a nanoporous material with good biocompatibility, stability, large pore size and specific surface area (SBET = 908 m2 g−1, VP = 0.79 cm3 g−1, d = 5.9 nm) and easy surface modification. To prepare the redox-responsive system, cystamine derivative ligands, with redox active disulphide linkers were grafted onto the surface of SBA-15. To ensure no significant premature release of DOX from the porous system, thioglycolic acid modified ZnS nanoparticles (ZnS–COOH NPs) were used as pore capping agents. The grafted redox-responsive cystamine derivative ligand containing disulphide linkers was bonded by a peptide bond to the thioglycolic acid groups of ZnS–COOH NPs, capping the pores. Once the disulphide bond was cleaved, the ZnS–COOH NPs caps were released and pores were opened to deliver the DOX cargo. The dithiol bond was cleavable by redox active molecules such as dithiothreitol (DTT) or glutathione, the concentration of which in cancer cells is 4 times higher than in healthy cells. The redox release of DOX was studied in two different media, physiological saline solution with DTT and saline without DTT. The prepared DDS proved the concept of redox responsive release. All samples were characterised by powder X-ray diffraction (XRD), transition electron microscopy (TEM), nitrogen adsorption/desorption at 77 K, Fourier-transform infrared spectroscopy (FTIR), thermal analysis and zeta potential measurements. The presence of semiconducting ZnS nanoparticle caps on the pore openings was detected by magnetic measurements using SQUID magnetometry showing that such cargo systems could be monitored using magnetic measurements which opens up the possibilities of using such drug delivery systems as theranostic agents. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman and Martin R. Gill. Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment. Pharmaceutics, 2021, 13, 152. DOI: 10.3390/pharmaceutics13020152
Baranya Murugan, Suresh Sagadevan, Is Fatimah, Won-Chun Oh, Mohd Abd Motalib Hossain and Mohd Rafie Johan. Smart stimuli-responsive nanocarriers for the cancer therapy – nanomedicine. Nanotechnology Reviews, 2021, 10, 933. DOI: 10.1515/ntrev-2021-0067
Adriana Zeleňáková, Jaroslava Szűcsová, Ľuboš Nagy, Vladimír Girman, Vladimír Zeleňák and Veronika Huntošová. Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen. Nanomaterials, 2021, 11, 901 DOI: 10.3390/nano11040901
Milad Abniki, Zahra Azizi and Homayon Ahmad Panahi. Design of 3‐aminophenol‐grafted polymer‐modified zinc sulphide nanoparticles as drug delivery system. IET nanobiotechnol., 2021, 15, 664. DOI: 10.1049/nbt2.12063.
Ndumiso Vukile Mdlovu, Kuen-Song Lin, Meng-Tzu Weng, Chi-Cheng Hsieh, You-Sheng Lin and Maria Janina Carrera Espinoza. In vitro intracellular studies of pH and thermo-triggered doxorubicin conjugated magnetic SBA-15 mesoporous nanocarriers for anticancer activity against hepatocellular carcinoma Journal of Industrial and Engineering Chemistry, 2021, 102, 1 DOI: 10.1016/j.jiec.2021.06.004 |
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| OCA18. Characteristics of the output's impact on socio-economic practice | The knowledge gained in the study can be used in the development of new drugs that can transport the active substance directly to a designated place in the body. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | |
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