| Basic data |
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| OCA1. Surname awarded to the assessed person | Mudroňová |
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| OCA2. Name awarded to the assessed person | Dagmar |
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| OCA3. Degrees awarded to the assessed person | Prof. , DVM, PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6094 |
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| OCA5. Area of assessment | study programme microbiology and immunology · III. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2021 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | 252705 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://pubmed.ncbi.nlm.nih.gov/33461599/ |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | ID: 252705 | Cellular and humoral peritoneal immunity to Mesocestoides vogae metacestode infection in mice / Mačák Kubašková, Terézia [Autor, 60%] ; Mudroňová, Dagmar [Autor, 20%] ; Vargová, Miroslava [Autor, 5%] ; Reiterová, Katarína [Autor, 5%] ; Hrčková, Gabriela [Autor, 10%]. – DOI 10.1186/s13071-020-04541-0. – WOS CC ; SCO
In: Parasites & Vectors [elektronický dokument] . – Londýn (Veľká Británia) : Springer Nature. BioMed Central. – ISSN (online) 1756-3305. – Roč. 14, č. 1 (2021), art. no. 54, s. [1-19] [online] |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-020-04541-0 |
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| OCA14. Characteristics of the author's contribution | The author is the implementer of the output. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | Larval cestodiases are zoonotic diseases caused by the larval stages of tapeworms. They represent infections of veterinary, medical and economic importance with a worldwide distribution. The modulation of immune response is a key component of Mesocestoides vogae pathogenesis. Only a few previous studies have investigated immune-related host events, but the mechanisms that provide long-lasting protection for parasites are still unclear. In infected mice we observed that M. vogae induced the recruitment of immunosuppressive cell subpopulations, which may play a key role in the downregulation of immune response in long-term parasitic diseases, and excretory-secretory antigens seem to be the main regulatory factor. The increasing parasite burden was associated with a higher IL-10 level and consistently upregulated the expression of STAT-3, which could be one of the regulatory mechanisms in M. vogae infection to control the release of pro-inflammatory cytokines. Understanding the molecular interactions between the parasite and its host that drives immune modulation could lead to the development of new strategies for managing metacestode infections. |
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| Other data |
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| OCA16. Annotation of the output in English | Here, Mesocestoides (M.) vogae infection in mice is proposed as a suitable experimental model for studying the immunity in the peritoneal cavity of mice. In the peritoneal cavity an initial increase of CD11b+Gr-1+F4/80highMHC IIhigh cells, NK, NKT cells and CD8+ cytotoxic T cells was observed in the first week of infection. At day 14 post-infection, an increase in the number of myeloid CD11b+Gr-1+ cells was detected, and most of this cell population expressed low levels of F4/80 and MHC II in later stages of infection, suggesting the impairment of antigen-presenting cell functions, probably through the excretory-secretory molecules. Moreover, we confirmed that peritoneal Gr1+ cells (Ly6C+ and Ly6G+ population) are phenotypically and functionally consistent with myeloid-derived suppressor cells. Metacestode infection elicited high levels of IL-10 and upregulated STAT-3 in peritoneal cells. A higher level of IgM suggests that this isotype may be predominant and is involved in the host protection. M. vogae tetrathyridia induced the recruitment of immunosuppressive cell subsets, which may play a key role in the downregulation of immune response in long-term parasitic diseases, and excretory-secretory antigens seem to be the main regulatory factor. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | Zhang, C., Wang, H., Aji, T. et al. Targeting myeloid-derived suppressor cells promotes antiparasitic T-cell immunity and enhances the efficacy of PD-1 blockade (15 words). Nat Commun 15, 6345 (2024). https://doi.org/10.1038/s41467-024-50754-7 (WoS)
Schreiber M, Macháček T, Vajs V, Šmídová B, Majer M, Hrdý J, Tolde O, Brábek J, Rösel D, Horák P: Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti tapeworms,Frontiers in Immunology, 15,2024,10.3389/fimmu.2024.1376907
Huan Chen, Lin Li, Hui Liu. Tapeworm infection and secondary hemorrhagic shock found after cervical cancer surgery: a case report. European Journal of Gynaecological Oncology. 2023. 44(1);119-122
Stevenson MM, Valanparambil RM and Tam M (2022) Myeloid-Derived Suppressor Cells: The Expanding World of Helminth Modulation of the Immune System. Front. Immunol. 13:874308. doi: 10.3389/fimmu.2022.874308 |
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| OCA18. Characteristics of the output's impact on socio-economic practice | The results of the output clarified the mechanism of the immunosuppressive action of the parasite Mesocestoides vogae. The results thus contribute to clarifying the long-term survival of flatworms in the host\'s organism. The knowledge gained is also used in research, where mice infected with M. vogae are used as a model for the study of immunosuppressive conditions in humans. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | The output brings new knowledge about the immune response of mice after infection with the parasite Mesocestoides vogae. The acquired knowledge will be used for studies on the immunosuppressive model of mice as well as for the education of students in the 3rd degree of university studies in the Microbiology and Immunology program. |
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