ID: 470397 | Mucosal barrier status in Atlantic salmon fed marine or plant-based diets supplemented with probiotics / Nadanasabesan, Nimalan [Autor, 5%] ; Sørensen, Solveig Lysfjord [Autor, 5%] ; Fečkaninová, Adriána [Autor, 30%] ; Koščová, Jana [Autor, 15%] ; Mudroňová, Dagmar [Autor, 15%] ; Gancarčíková, Soňa [Autor, 10%] ; Vatsos, Ioannis [Autor, 5%] ; Bisa, Saraswathy [Autor, 5%] ; Kiron, Viswanath [Autor, 5%] ; Sørensen, Mette [Autor, 5%]. – [recenzované]. – DOI 10.1016/j.aquaculture.2021.737516. – WOS CC ; SCO ; CCC In: Aquaculture [textový dokument (print)] [elektronický dokument] . – Amsterdam (Holandsko) : Elsevier. – ISSN 0044-8486. – ISSN (online) 1873-5622. – č. 547 (2022), art. no. 737516, s. [1-19] [tlačená forma] [online]

Basic data
OCA1. Surname awarded to the assessed person	Mudroňová
OCA2. Name awarded to the assessed person	Dagmar
OCA3. Degrees awarded to the assessed person	Prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6094
OCA5. Area of assessment	study programme microbiology and immunology · III. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2022
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	470397
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioForm&sid=37166900746EB0FDF1C2857C9A
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.sciencedirect.com/science/article/pii/S0044848621011790
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	ID: 470397 \| Mucosal barrier status in Atlantic salmon fed marine or plant-based diets supplemented with probiotics / Nadanasabesan, Nimalan [Autor, 5%] ; Sørensen, Solveig Lysfjord [Autor, 5%] ; Fečkaninová, Adriána [Autor, 30%] ; Koščová, Jana [Autor, 15%] ; Mudroňová, Dagmar [Autor, 15%] ; Gancarčíková, Soňa [Autor, 10%] ; Vatsos, Ioannis [Autor, 5%] ; Bisa, Saraswathy [Autor, 5%] ; Kiron, Viswanath [Autor, 5%] ; Sørensen, Mette [Autor, 5%]. – [recenzované]. – DOI 10.1016/j.aquaculture.2021.737516. – WOS CC ; SCO ; CCC In: Aquaculture [textový dokument (print)] [elektronický dokument] . – Amsterdam (Holandsko) : Elsevier. – ISSN 0044-8486. – ISSN (online) 1873-5622. – č. 547 (2022), art. no. 737516, s. [1-19] [tlačená forma] [online]
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://doi.org/10.1016/j.aquaculture.2021.737516
OCA14. Characteristics of the author's contribution	The author is one of the bearers of the main idea of the output and at the same time the implementer and creator of the output.
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	We investigated the ability of lactic acid bacteria, when added individually or in combination in feeds, to prevent soybean meal-induced enteritis in Atlantic salmon. Three more diets were produced by coating the control diet with two bacteria, either singly (Lactobacillus plantarum; L. fermentum) or in combination. We performed histological assessments and evaluated the expression of selected mucin and antimicrobial peptide genes in the dorsal skin, gills, and distal intestine. Digesta were also collected to study the short chain fatty acids. The most important findings were: (1) L. plantarum-L. fermentum combination can counter enteritis in salmon. (2) The probiotic combination increased the short-chain fatty acids in chyme. (3) L. plantarum significantly upregulated defensin1 in the skin and lactic acid in chyme. (4) The probiotic combination stimulated acetoacetic and succinic acids in chyme. (5) L. fermentum increased propionic acid in chyme.
Other data
OCA16. Annotation of the output in English	Feed ingredients and additives significantly affect the mucosal health of fish.The experiment was conducted to investigate the mucosal health of Atlantic salmon (Salmo salar) fed three basal feeds (marine-, plant-, and soybean meal-based feeds) or the basal feeds with (+) or without (÷) probiotics, Lactobacillus fermentum and Lactobacillus plantarum. Our findings suggest that feed ingredients can significantly alter the mucosal protective barrier of the organs. Supplementation of probiotics alleviated the inflammatory responses and activated selected innate immune defence molecules, without affecting growth. The positive effect of the probiotics was similar regardless of the feed ingredients, suggesting that these probiotics can be utilized as immune regulators to evoke favourable responses on the skin, gills and intestine.
OCA17. List of maximum 5 most significant citations corresponding to the output	1. Sharifian, M., English, C.J., Whitehead, D.L., Barnes, A.C. Changes in mucosal epithelia of marine Atlantic salmon (Salmo salar) under chronic heat stress,(2025) Aquaculture, 598, art. no. 742064. 2. Merkin, G.V., Girons, A., Okubamichael, M.A., Pittman, K. Mucosal epithelial homeostasis: Reference intervals for skin, gill lamellae and filament for Atlantic salmon and other fish species,(2025) Journal of Fish Diseases, 48 (1), art. no. e14023. 3. Metin, Ö., Yildiz, M., Eldem, V., Adabi, S.G. The effects of using hydrolyzed feather meal, amino acids, and probiotics in the diet of juvenile rainbow trout on growth, digestibility, and expression of growth-related genes, (2024) Aquaculture International, 32 (7), pp. 9671-9693. 4. Islam, S.M., Willora, F.P., Sørensen, M., Rbbani, G., Siddik, M.A.B., Zatti, K., Gupta, S., Carr, I., Santigosa, E., Brinchmann, M.F., Thompson, K.D., Vatsos, I.N. Mucosal barrier status in Atlantic salmon fed rapeseed oil and Schizochytrium oil partly or fully replacing fish oil through winter depression, (2024) Fish and Shellfish Immunology, 149, art. no. 109549. 5. Liu, Z.-Y., Yang, H.-L., Li, S., Cai, G.-H., Ye, J.-D., Zhang, C.-X., Sun, Y.-Z. Paraprobiotic and postbiotic forms of Bacillus siamensis improved growth, immunity, liver and intestinal health in Lateolabrax maculatus fed soybean meal diet, (2024) Fish and Shellfish Immunology, 145, art. no. 109370.
OCA18. Characteristics of the output's impact on socio-economic practice	The output clarifies the possibility of using probiotic bacteria to reduce inflammation and intestinal damage in Atlantic salmon after feeding a commercial soy-based diet, which has a strong pro-inflammatory effect. The output was one of the bases for the submission of a joint Slovak-Norwegian patent application for probiotic feed at the Norwegian Office for the Protection of Intellectual Property and the development of further cooperation between the University of Veterinary Medicine and Pharmacy in Košice and Nord University in Bodo, Norway.
OCA19. Characteristics of the output and related activities' impact on the educational process	The output brings new knowledge about the influence of probiotic bacteria on the immunity and gut health of salmonid fish. This knowledge will be used for further education of students in the 3rd level of university studies in the Microbiology and immunology program as well as students of veterinary medicine.