Differential transcriptome response of blood brain barrier spheroids to neuroinvasive Neisseria and Borrelia/Kulkarni Amod, Jozefiaková Jana, Bhide Katarína, Mochnáčová Evelína, Bhide Mangesh

Basic data
OCA1. Surname awarded to the assessed person	Bhide
OCA2. Name awarded to the assessed person	Mangesh Ramesh
OCA3. Degrees awarded to the assessed person	prof. MVSc., PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/6102
OCA5. Area of assessment	study programme microbiology and immunology · III. degree
OCA6. Category of the research/artistic/other output
OCA7. Year of publication of the research/artistic/other output	2023
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	1116774
OCA9. Hyperlink to the record in CRPA or CRAA	https://app.crepc.sk/?fn=detailBiblioFormChildC2VQT1&sid=82E8E2F14D9232B3C0ACA36D4D93&seo=CREPČ-detail-Článok
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1326578/full
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	Differential transcriptome response of blood brain barrier spheroids to neuroinvasive Neisseria and Borrelia/Kulkarni Amod, Jozefiaková Jana, Bhide Katarína, Mochnáčová Evelína, Bhide Mangesh
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1326578/full
OCA14. Characteristics of the author's contribution	author is the bearer of ideas and the main researcher of all research in the field
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.	The self-assembling spheroids were used to perceive the BBB response to neuroinvasive pathogens - Neisseria and Borrelia. Compromised integrity of spheroids during Neisseria and Borrelia infection as opposed to its intactness and non-adherence of E. coli (non-neuroinvasive) denotes the pathogen dependent fate of BBB. Genes categorized into various biological functions indicated weakened barrier properties of BBB and heightened innate immune response. Inverse expression of 48% genes commonly identified during Neisseria and Borrelia infection exemplifies unique response of BBB to varying neuropathogens.
Other data
OCA16. Annotation of the output in English	The output elucidates the biological processes taking place in brain endothelial cells after their induction by Streptococcus pneumoniae (SP) and its ligand laminin binding protein. Data from transcriptome analysis were processed using innovative bioinformatics tools. The elucidation of cell transcriptome forms the basis for understanding the process of SP translocation across the blood-brain barrier. These findings can be used in the development of ligand-blocking therapeutic agents
OCA17. List of maximum 5 most significant citations corresponding to the output
OCA18. Characteristics of the output's impact on socio-economic practice	The output elucidates the biological processes taking place in brain endothelial cells after their induction by Streptococcus pneumoniae (SP) and its ligand laminin binding protein. Data from transcriptome analysis were processed using innovative bioinformatics tools. The elucidation of cell transcriptome forms the basis for understanding the process of SP translocation across the blood-brain barrier. These findings can be used in the development of ligand-blocking therapeutic agents.
OCA19. Characteristics of the output and related activities' impact on the educational process	Vystup objasňuje biologické procesy prebiehajúce v mozgových endotelových bunkách po ich indukcii .Dáta z transkriptómovej analýzy boli spracované pomocou inovatívnych bioinformatických nástrojov. Objasnenie transkriptómu buniek vytvára základňu pre pochopenie procesu translokácie SP cez hematoencefalickú bariéru. Tieto poznatky môžu byť využité pri vývoji ligand-blokujúcich terapeutických látok / The output elucidates the biological processes taking place in brain endothelial cells after their induction by Streptococcus pneumoniae (SP) and its ligand laminin binding protein. Data from transcriptome analysis were processed using innovative bioinformatics tools. The elucidation of cell transcriptome forms the basis for understanding the process of SP translocation across the blood-brain barrier. These findings can be used in the development of ligand-blocking therapeutic agents