Pilátová Martina, Varinská Lenka, Perjési Pál, Šarišský Marek, Mirossay Ladislav, Solár Peter, Ostró Alexander, Mojžiš Ján: In vitro antiproliferative and antiangiogenic effects of synthetic chalcone analogues. Toxicology in Vitro. - ISSN 0887-2333. - Vol. 24, no. 5 (2010), s. 1347-1355.

Basic data
OCA1. Surname awarded to the assessed person	Bago Pilátová
OCA2. Name awarded to the assessed person	Martina
OCA3. Degrees awarded to the assessed person	Assoc. prof. , DVM, PhD
OCA4. Hyperlink to the entry of the person in the Register of university staff	https://www.portalvs.sk/regzam/detail/15102
OCA5. Area of assessment	study programme pharmacy (joint study programme) · I. + II. degree
OCA6. Category of the research/artistic/other output	scientific output
OCA7. Year of publication of the research/artistic/other output	2010
OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA)	UPJŠ.Košice..000040248
OCA9. Hyperlink to the record in CRPA or CRAA
Characteristics of the output that is not registered in CRPA or CRAA
OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs	http://www.crepc.sk/portal?fn=*recview&uid=131432&pageId=resultform&full=0
OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs	Pilátová Martina, Varinská Lenka, Perjési Pál, Šarišský Marek, Mirossay Ladislav, Solár Peter, Ostró Alexander, Mojžiš Ján: In vitro antiproliferative and antiangiogenic effects of synthetic chalcone analogues. Toxicology in Vitro. - ISSN 0887-2333. - Vol. 24, no. 5 (2010), s. 1347-1355.
OCA12. Type of the output (if the output is not registered in CRPA or CRAA)	article
OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.)	https://www.sciencedirect.com/science/article/pii/S0887233310000962?via%3Dihub
OCA14. Characteristics of the author's contribution
OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc.
Other data
OCA16. Annotation of the output in English	Chalcones have a wide range of biologically beneficial properties, so we studied E-2- (4\\\'-methoxybenzylidene) -1-benzosuberone and its antiproliferative effects on Jurkat and HeLa cells and antiangiogenic effects on HUVEC (Human umbilical vein endothelial cells). After incubation of the tumor cells with the tested chalcone, there was a blockade in the G2 / M phase of the cell cycle and subsequent apoptosis associated with DNA fragmentation, downregulation of antiapoptotic Bcl-2 and ovrexpression of proapototic Bax. In HUVEC cells at non-toxic concentrations, it inhibited VEGF-induced migration and decreased the production of MMP-9 and VEGF. Based on these results, we can assume that this compound has antiproliferative and antiangiogenic properties.
OCA17. List of maximum 5 most significant citations corresponding to the output	RODRIGUES, J. et al. New 4-Maleamic Acid and 4-Maleamide Peptidyl Chalcones as Potential Multitarget Drugs for Human Prostate Cancer. In Pharmaceutical Research, 2011, vol. 28, no. 4, p. 907-919. doi: 10.1007/s11095-010-0347-8. (IF=4,981) RUIZ-MONTAÑEZ, G. et al. Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam). In Food Chemistry, 2015, vol. 175, s. 409-416. doi: 0.1016/j.foodchem.2014.11.122. (IF 4,192) WANGNGAE, S. et al. Photophysical study and biological applications of synthetic chalcone-based fluorescent dyes. In Molecules, 2021, roč. 26, č. 10, art. no. 2979. doi:10.3390/molecules26102979. (IF=4,148) MIELCKE, T.R. et al. Activity of novel quinoxaline-derived ... In European Journal of Medicinal Chemistry, 2012, vol. 48, no. 2, s. 255-264. doi:10.1016/j.ejmech.2011.12.023. (IF=3,996) SHARMA, R. et al. A review on mechanisms of anti tumor activity of chalcones. In Anti-Cancer Agents in Medicinal Chemistry, 2016, vol. 16, no. 2, s. 200-211. doi: 10.2174/1871520615666150518093144. (IF=2,617)
OCA18. Characteristics of the output's impact on socio-economic practice	Many currently used drugs have been created by structural modification of natural substances, which play an important role in the treatment of many diseases, including cancer. Despite advances in the diagnosis and development of new treatments, cancer is one of the most common causes of death. Their current therapy is associated with a number of side effects, which is related to its non-selective action. For this reason, scientific teams are trying to find new compounds with lower toxicity and a better therapeutic response. This article discusses the antiproliferative and antiangiogenic effects of newly synthesized chalcones, which could be helpful in finding new structures for anticancer drugs.
OCA19. Characteristics of the output and related activities' impact on the educational process	General pharmacology also includes the development of new drugs, including preclinical drugs. This issue is part of the pharmacology syllabus. The work enables medical and doctoral students to gain at least a simplified view of the complexity of the process of finding new compounds with potential antiproliferative effect in the basic preclinical screening phase in in vitro experiments at the cellular and subcellular level.