| Basic data |
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| OCA1. Surname awarded to the assessed person | Bago Pilátová |
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| OCA2. Name awarded to the assessed person | Martina |
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| OCA3. Degrees awarded to the assessed person | Assoc. prof. , DVM, PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/15102 |
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| OCA5. Area of assessment | study programme pharmacy (joint study programme) · I. + II. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2025 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | ID: 1295150 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://app.crepc.sk/?fn=detailBiblioForm&sid=D7EC722BA8A89CA212E31CD3401B |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | Nosálová, Natália ; Majirská, Monika ; Kešeľaková, Alexandra ; Martinková, Miroslava ; Fabiánová, Dominika ; Miroššay, Andrej ; Bago Pilátová, Martina ; Kello, Martin: Pyrrolidine SS13 induces oxidative stress and autophagy-mediated cell death in colorectal cancer cells.
European Journal of Pharmaceutical Sciences, 2025, č. 205 |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.sciencedirect.com/science/article/pii/S0928098724002951 |
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| OCA14. Characteristics of the author's contribution | |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | |
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| Other data |
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| OCA16. Annotation of the output in English | Pyrrolidines are currently among the most intensively studied nitrogen-containing compounds due to their diverse pharmacological properties, including antitumor activity. This study investigates the pro-oxidative effects and autophagy-inducing potential of pyrrolidine SS13 in colorectal cancer cell lines HCT116 and Caco-2. Using flow cytometry, qRT-PCR, fluorescence microscopy, and Western blot analysis, the study demonstrated that SS13 induces oxidative stress through the accumulation of reactive oxygen and nitrogen species, modulates the levels of superoxide dismutase isoenzymes (SOD1 and SOD2), and activates DNA damage response pathways. Importantly, SS13 triggers autophagy, as evidenced by increased levels of autophagy markers (p-AMPK, p-ULK, LC3I/II, and ATG7) and decreased levels of the p62 protein. The cytotoxic effect of SS13 was reduced in the presence of chloroquine, confirming its role in autophagy-mediated cell death. These findings suggest that SS13 exerts antiproliferative effects through oxidative stress and autophagy activation. The results support the need for further in vivo and ex vivo studies to explore the therapeutic potential of pyrrolidine derivatives in the treatment of colorectal cancer |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | LAOSINWATTANA, Chamroon - MANICHART, Nutcha - WICHITTRAKARN, Pattharin - YONEYAMA, Kaori - TEERARAK, Montinee - PASSARA, Hataichanok. Impact of Nigrospora oryzae-Derived Natural Products on Photosynthesis and Oxidative Stress in Eichhornia crassipes. In Physiologia plantarum, 2025, roč. 177, č. 1., (2024 IF: 5.4; Q1) |
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| OCA18. Characteristics of the output's impact on socio-economic practice | The findings of this study on the pro-oxidative and autophagy-inducing effects of pyrrolidine SS13 in colorectal cancer cells have the potential to significantly impact socio-economic practice. If the efficacy and safety of this compound are confirmed in further preclinical and clinical studies, SS13 could serve as a foundation for the development of a new targeted anticancer drug. This may lead to improved treatment options for patients with colorectal cancer, reduced treatment costs due to more effective therapy, and consequently, a lower burden on the healthcare system. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | |
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