| Basic data |
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| OCA1. Surname awarded to the assessed person | Solárová |
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| OCA2. Name awarded to the assessed person | Zuzana |
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| OCA3. Degrees awarded to the assessed person | Assoc. prof. , M.D., PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/15120?mode=full |
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| OCA5. Area of assessment | study programme pharmacy (joint study programme) · I. + II. degree |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2017 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | |
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| OCA9. Hyperlink to the record in CRPA or CRAA | http://www.crepc.sk/portal?fn=*recview&uid=2199096&pageId=resultform&full=0 |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | Solárová Zuzana, Kello Martin, Varinská Lenka, Budovská Mariana, Solár Peter: Inhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(4\'fluorophenylamino)- 4H-1,3-thiazine[6,5-b]indole in A2780cis cellsInhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(40fluorophenylamino)- 4H-1,3-thiazine[6,5-b]indole in A2780cis cells. Biomedicine & Pharmacotherapy. - ISSN 0753-3322. - Vol. 85 (2017), s. 463-471.
ADC - Vedecké práce v zahraničných karentovaných časopisoch IF 3,457, Q1-SJR, citované 3x |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | |
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| OCA14. Characteristics of the author's contribution | SOLÁROVÁ, Zuzana (70%) - KELLO, Martin (10%) - VARINSKÁ, Lenka (5%) - BUDOVSKÁ, Mariana (5%) - SOLÁR, Peter (10%) |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | Ovarian cancer is initially sensitive to platinum-based therapy, but becomes resistant over time. The study of substances that sensitize tumor cells is therefore a major challenge for many scientific groups. Our experiments were performed on human ovarian adenocarcinoma A2780cis cells, which are resistant to cisplatin, and we examined their response to 2-(4\'-fluorophenylamino)-4H-1,3-thiazine[6,5-b]indole (thiazine[6,5-b]indole) and/or the heat shock protein (Hsp) inhibitor 90, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) using proliferation assay, cell cycle analysis and apoptosis monitoring. A2780cis cells showed the same degree of resistance to the Hsp90 inhibitor 17-DMAG as reported for cisplatin (18-fold), but only 3.2-fold to thiazine[6,5-b]indole. Our results showed that the combination of thiazine[6,5-b]indole and 17-DMAG significantly reduced the proliferation of A2780cis cells and led to their accumulation in the G2/M phase of the cell cycle. |
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| Other data |
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| OCA16. Annotation of the output in English | Ovarian carcinoma is initially sensitive to platinum-based therapy, but become resistant over time. The study of cancer sensitizing substance is therefore the major challenge for a number of scientific groups. Our experiments were carried out on human ovarian adenocarcinoma A2780cis cells resistant to cisplatin and their response to 2-(4\'fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole (thiazine[6,5-b]indole) and/or heat shock protein (Hsp) 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) using proliferation assay, cell cycle analysis and monitoring of apoptosis were examined. A2780cis cells revealed the same fold of resistance to Hsp90 inhibitor 17-DMAG as it is declared for cisplatin (18 times), but only 3.2 times for thiazine[6,5-b]indole. Our results showed that the combination of thiazine[6,5-b]indole and 17-DMAG significantly reduced proliferation of A2780cis cells and led to their accumulation in G2/M phase of the cell cycle. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | JIA, Y. et al. Current scenario of indole derivatives with potential anti-drug-resistant cancer activity. In European Journal of Medicinal Chemistry, 2020, vol. 200, art. no. 112359, doi: 10.1016/j.ejmech.2020.112359. (IF=6,51)
BENITES, J. et al. Targeting Akt as strategy to kill cancer cells using 3-substituted 5-anilinobenzo[c]isoxazolequinones: A preliminary study. In Biomedicine and Pharmacotherapy, 2018, vol. 97, doi: doi: 10.1016/j.biopha.2017.10.108. (IF 3,457) |
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| OCA18. Characteristics of the output's impact on socio-economic practice | The work is focused towards anticancer effects of drugs and the search for their new targets. We have been dealing with this issue at the institute for a long time. This review article focuses on the heat shock protein HSP90, which is highly expressed in tumor cells and thus appears to be a new promising target for some drugs, including many substances of natural origin, such as thiazine-indole. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | /The anticancer drugs are part of lectures for medical students. For PhD students, the potential antitumor effect of natural substances is an important part of their studies. This work can help them understand the new targets for many of anticancer drugs. |
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