| Basic data |
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| OCA1. Surname awarded to the assessed person | Bhide |
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| OCA2. Name awarded to the assessed person | Mangesh Ramesh |
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| OCA3. Degrees awarded to the assessed person | prof. MVSc., PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6102 |
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| OCA5. Area of assessment | habilitation and inauguration procedure – microbiology and immunology |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2025 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | ID = 1457840 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioForm&sid=0278C0DD79B92F655A5864236996 |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://www.scopus.com/pages/publications/105019590634?origin=resultslist |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | BHIDE, Katarína - SLÁVIKOVÁ, Monika - TALPAŠOVÁ, Lea - KUCKOVÁ, Katarína - KLEMPA, Boris - TYAGI, Punit - BHIDE, Mangesh Ramesh. Comprehensive mapping of the signaling events evoked by SARS-CoV-2 variants delta and omicron in human astrocytes. In: Scientific Reports. 2025. ISSN 2045-2322, Vol. 15, no. 1 (2025), art. no. 36897, p. [1-18]
(2024: 3.900 - IF, 347 - H-index, 4.300 - IF 5y, 0.874 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q) |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.nature.com/articles/s41598-025-20851-8 |
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| OCA14. Characteristics of the author's contribution | The author is the bearer of ideas and the main researcher of all research in the field. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | |
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| Other data |
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| OCA16. Annotation of the output in English | COVID-19 causes a wide range of complications in the central nervous system, including encephalitis and other neurological symptoms such as memory problems, psychological disorders, depression, and anxiety. We present comprehensive data on the changes in gene expression levels in astrocytes infected with the Delta or Omicron variants of SARS-CoV-2. In RNA-seq data, we found 346 genes that were significantly evoked (197 up- and 149 down-regulated) in astrocytes challenged with the Omicron variant, compared to 341 evoked genes (215 up- and 126 down-regulated) in the Delta variant. A surprisingly large number of genes were exclusively evoked by Delta (82 up- and 48 downregulated) and Omicron variants (65 up and 60 downregulated). Numerous pathways, including those pertaining to the neuronal system, metabolism, response to viral infection, signal transduction, cytokine signaling, and homeostasis, were dysregulated in infected astrocytes. In this report we have dissected major pathways that are related to pathogen recognition, integrity of the BBB and glia limitans, and neurological disorders that could lead to neurological symptoms listed above. Our findings also reveal dysregulation of a large number of non-coding RNAs. The data presented here may help us better understand the role of astrocytes in the neurological disorders seen in COVID-19 patients. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | |
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| OCA18. Characteristics of the output's impact on socio-economic practice | Clarifying the impact of SARS-CoV-2 on astrocyte functionality and partially explaining the neurological symptoms of COVID-19. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | Study and understanding of neuroinfection caused by SARS-CoV-2. |
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