| Basic data |
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| OCA1. Surname awarded to the assessed person | Bhide |
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| OCA2. Name awarded to the assessed person | Mangesh Ramesh |
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| OCA3. Degrees awarded to the assessed person | prof. MVSc., PhD |
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| OCA4. Hyperlink to the entry of the person in the Register of university staff | https://www.portalvs.sk/regzam/detail/6102 |
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| OCA5. Area of assessment | habilitation and inauguration procedure – microbiology and immunology |
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| OCA6. Category of the research/artistic/other output | scientific output |
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| OCA7. Year of publication of the research/artistic/other output | 2025 |
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| OCA8. ID of the record in the Central Registry of Publication Activity (CRPA) or the Central Registry of Artistic Activity (CRAA) | ID 1344615 |
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| OCA9. Hyperlink to the record in CRPA or CRAA | https://app.crepc.sk/?fn=detailBiblioFormChildMRIF&sid=591608704B394480C01CDCCFFE0D&seo=CREP%C4%8C-detail-%C4%8Cl%C3%A1nok |
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| Characteristics of the output that is not registered in CRPA or CRAA |
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| OCA10. Hyperlink to the record in another publicly accessible register, catalogue of research/ artistic/other outputs | https://www.scopus.com/pages/publications/105002828045?origin=resultslist |
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| OCA11. Characteristics of the output in the format of the CRPA or the CRAA bibliographic record, if the output is not available in a publicly accessible register or catalogue of outputs | PETROUŠKOVÁ, Patrícia - BHIDE, Katarína - MOCHNÁČOVÁ, Evelína - KULKARNI, Amod - JOZEFIAKOVÁ, Jana - TKÁČOVÁ, Zuzana - MAĽARIK, Tomáš - KUCKOVÁ, Katarína - TALPAŠOVÁ, Lea - VÍGLASKÝ, Jakub - KEVÉLY, Ádám - KOČI, Kamila - NOVÁKOVÁ, Eva - KOČI, Juraj - BHIDE, Mangesh Ramesh. Peptides developed against receptor binding sites of the E glycoprotein neutralize tick-borne encephalitis virus. In: Scientific Reports. 2025. ISSN 2045-2322, Vol. 15, no. 1 (2025), art. no. 11435, p. [1-15]
(2024: 3.900 - IF, 4.300 - IF 5y, 0.874 - SJR, Q1 - SJR Best Q, Q1 - JCR Best Q) |
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| OCA12. Type of the output (if the output is not registered in CRPA or CRAA) | article |
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| OCA13. Hyperlink to the webpage where the output is available (full text, other documentation, etc.) | https://www.nature.com/articles/s41598-025-95449-1 |
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| OCA14. Characteristics of the author's contribution | The author is the bearer of ideas and the main researcher of all research in the field. |
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| OCA15. Annotation of the output with contextual information concerning the description of creative process and the content of the research/artistic/other activity, etc. | |
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| Other data |
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| OCA16. Annotation of the output in English | Infection caused by tick-borne encephalitis virus (TBEV) often manifests with meningitis or encephalitis. Domain III (DIII) of the envelope (E) glycoprotein on the TBEV surface facilitates virion attachment to the cell receptor and initiates cell entry. As a result, this research focused on the DIII to develop antiviral molecules that could prevent cell entry. We first identified two receptor-binding sites (RBS, 300SGLTYTMCDK309 and 317APTDSGHDTVVMEVTFSGTKPCR339) on DIII, that are involved in binding to human brain microvascular endothelial cells (hBMECs). Then we sought to isolate peptides from two combinatorial peptide-phage libraries that bind to the RBS and prevent protein E from attaching to hBMECs. Three cyclic peptides (CP2-CNSSKLHMC, CP20-CDGRPDRAC, CP23-CMKESIRGC) and a linear peptide (LP16-AFHPRQMETQMY) inhibited DIII binding to hBMECs. CP2 and CP20, both non-cytotoxic and hemocompatible, effectively neutralized a live virus. CP2 and CP20 deserve further attention for their potential application as anti-TBEV therapeutics that prevent viral cell entry. |
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| OCA17. List of maximum 5 most significant citations corresponding to the output | 2025: [1] TARE, Maria Violeta R. - ALMAZAN, Debrah Jannsen D. J. N. - SAQUILAYAN, Krisha Marie D. L. - GLORI, Patricia Jhoanna V. - SOLITARIO, Jim Troy - MANINGAS, Mary Beth B. A review of host and pathogen gene targets for RNAi therapeutics in shrimp disease mitigation. In DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2025, vol. 172, no., pp. ISSN 0145-305X. Dostupné na: https://doi.org/10.1016/j.dci.2025.105482. |
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| OCA18. Characteristics of the output's impact on socio-economic practice | Development of therapeutics based on the principle of blocking the entry of TBEV virus into the host cell. |
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| OCA19. Characteristics of the output and related activities' impact on the educational process | Studying the interaction between TBEV and host cells and developing new therapeutics using modern interdisciplinary approaches. |
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