PHB/CHIT scaffold as a promising biopolymer in the treatment of osteochondral defects—an experimental animal study

GHOLAMI, Reyhan - MOHAMMADALIPOUR, Mohammad - ASTARAKI, Hesamodin. Advancements in Polyhydroxybutyrate-Based Scaffolds for Tissue Engineering Through Pre and Postprocessing Modifications. In ADVANCES IN POLYMER TECHNOLOGY, 2026, vol. 2026, no. 1, pp. ISSN 0730-6679. Dostupné na: https://doi.org/10.1155/adv/3728039.

HAJAREH HAGHIGHI, Farid - BINAYMOTLAGH, Roya - PINTILEI, Paula Stefana - CHRONOPOULOU, Laura - PALOCCI, Cleofe. From Waste to Treasure: Therapeutic Horizons of Polyhydroxyalkanoates in Modern Medicine. In PHARMACEUTICS. Vol. 18, no. 1 (2026), pp. Dostupné na: https://doi.org/10.3390/pharmaceutics18010082.

JOSINO, Raphaella - VILLANOVA JUNIOR, Jose Ademar - KUPCZIK, Fabiano - CAPRIGLIONE, Luiz Guilherme Achcar - SCHAIDT, Bruna - BARCHIKI, Fabiane - BOLDRINI-LEITE, Lidiane Maria - BROFMAN, Paulo Roberto Slud - CORREA, Alejandro - STIMAMIGLIO, Marco Augusto - REBELATTO, Carmen Lucia Kuniyoshi. Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect. CAMBRIDGE : JOURNAL OF VISUALIZED EXPERIMENTS, 2026. Dostupné na: https://doi.org/10.3791/68842. ISSN 1940-087X.

JAIN, Sunita. Polyhydroxyalkanoates Based Biomaterials in Tissue Repair and Regeneration. In Biopolymer Based Composites for Regenerative Medicines and Tissue Engineering Applications, 2025-10-22, pp. 283-332. ISBN [9781032851174, 9781003518792]. Dostupné na: https://doi.org/10.1201/9781003518792-10.

LI, Jian - ZHANG, Xu - ZHANG, Peng. Polyhydroxyalkanoates (PHAs) as biomaterials for the regeneration of bone tissue. In Polyhydroxyalkanoates Sustainable Production and Biotechnological Applications III Biomedical Sector, 2025-03-19, pp. 51-80. ISBN [9789819620210, 9789819620227]. Dostupné na: https://doi.org/10.1007/978-981-96-2022-7_3.

SARKAR, Kishor - MALLICK, Baisakhi. Functionalized biopolymer composites for biomedical and healthcare applications. In Functionalized Biopolymers Design Developments and Applications, 2025-01-01, pp. 297-355. ISBN [9780443273513, 9780443273506]. Dostupné na: https://doi.org/10.1016/B978-0-443-27350-6.00014-6.

SHARMA, Garima. Synthesis and Degradability Studies of Bioplastic Composites for Biomedical Applications. In Bioplastics Synthesis Characterization and Applications, 2025-10-21, pp. 161-198. ISBN [9781779643322, 9781003637561]. Dostupné na: https://doi.org/10.1201/9781003637561-8.

YOUSEFI, Amy M. - WNEK, Gary E. Poly(hydroxyalkanoates): Emerging Biopolymers in Biomedical Fields and Packaging Industries for a Circular Economy. In Biomedical Materials and Devices, 2025-03-01, 3, 1, pp. 19-44. ISSN 27314812. Dostupné na: https://doi.org/10.1007/s44174-024-00166-4.

ZHANG, Xiaoyang - JIANG, Weibo - DANZENG, Quezhu - SHEN, Yi - CUI, Mengying. Osteochondral tissue engineering‑based subchondral bone plate repair (Review). In Molecular Medicine Reports, 2025-06-01, 31, 6, pp. ISSN 17912997. Dostupné na: https://doi.org/10.3892/mmr.2025.13517.

ZHENG, Bowen - XING, Jiawei - TANG, Xuehan - HE, Ze - TANG, Qingran - LIU, Shibo - XIAO, Yin - XU, Jiazhuang - LUO, En - LIU, Yao. Tailored surface topographical scaffolds: a breakthrough in osteoarthritic cartilage and subchondral bone defect repair. In JOURNAL OF MATERIALS CHEMISTRY B, 2025, vol. 13, no. 29, pp. 8639-8652. ISSN 2050-750X. Dostupné na: https://doi.org/10.1039/d5tb00943j.

BRODA, Magdalena - YELLE, Daniel J. - SERWAŃSKA-LEJA, Katarzyna. Biodegradable Polymers in Veterinary Medicine—A Review. In Molecules, 2024-02-01, 29, 4, pp. Dostupné na: https://doi.org/10.3390/molecules29040883.

CHABER, Paweł - ANDRÄ-ŻMUDA, Silke - ŚMIGIEL-GAC, Natalia - ZIĘBA, Magdalena - DAWID, Kamil - MARTINKA MAKSYMIAK, Magdalena - ADAMUS, Grażyna. Enhancing the Potential of PHAs in Tissue Engineering Applications: A Review of Chemical Modification Methods. In Materials, 2024-12-01, 17, 23, pp. Dostupné na: https://doi.org/10.3390/ma17235829.

CUI, Mengying - SUN, Yang - ZHANG, Xiaoyang - YANG, Pengju - JIANG, Weibo. Osteochondral tissue engineering in translational practice: histological assessments and scoring systems. In Frontiers in Bioengineering and Biotechnology, 2024-01-01, 12, pp. Dostupné na: https://doi.org/10.3389/fbioe.2024.1434323.

MURUGAN, Baranya - FATIMAH, Is - HOSSAIN, M. A.Motalib - SAGADEVAN, Suresh. Biopolymer-Based Nanomaterials and Their Applications. In Green Synthesis of Nanomaterials: Biological and Environmental Applications, 2024-01-01, pp. 71-88.

XIONG, Ziqi - HONG, Fangyuan - WU, Zhonglin - REN, Yijia - SUN, Nuola - HENG, Boon Chin - ZHOU, Jing. Gradient scaffolds for osteochondral tissue engineering and regeneration. In Chemical Engineering Journal, 2024-10-15, 498, pp. ISSN 13858947. Dostupné na: https://doi.org/10.1016/j.cej.2024.154797.

DHANIA, Sunena - BERNELA, Manju - RANI, Ruma - PARSAD, Minakshi - GREWAL, Sapna - KUMARI, Santosh - THAKUR, Rajesh. Scaffolds the backbone of tissue engineering: Advancements in use of polyhydroxyalkanoates (PHA). In INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, vol. 208, no., pp. 243-259. ISSN 0141-8130. Dostupné na: https://doi.org/10.1016/j.ijbiomac.2022.03.030.

GUO, Wentai - YANG, Keli - QIN, Xiusen - LUO, Rui - WANG, Hui - HUANG, Rongkang. Polyhydroxyalkanoates in tissue repair and regeneration. In Engineered Regeneration, 2022-03-01, 3, 1, pp. 24-40. Dostupné na: https://doi.org/10.1016/j.engreg.2022.01.003.

PULINGAM, Thiruchelvi - APPATURI, Jimmy Nelson - PARUMASIVAM, Thaigarajan - AHMAD, Azura - SUDESH, Kumar. Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering. In POLYMERS, 2022, vol. 14, no. 11, pp. Dostupné na: https://doi.org/10.3390/polym14112141.

RASHIDI, Ali - THERUVATH, Ashok J. - HUANG, Ching-Hsin - WU, Wei - MAHMOUD, Elhussein E. - RAJ, Joe Gerald Jesu - MARYCZ, Krzysztof - DALDRUP-LINK, Heike E. Vascular injury of immature epiphyses impair stem cell engraftment in cartilage defects. In SCIENTIFIC REPORTS, 2022, vol. 12, no. 1, pp. ISSN 2045-2322. Dostupné na: https://doi.org/10.1038/s41598-022-15721-6.

STRECANSKA, Magdalena - DANISOVIC, Lubos - ZIARAN, Stanislav - CEHAKOVA, Michaela. The Role of Extracellular Matrix and Hydrogels in Mesenchymal Stem Cell Chondrogenesis and Cartilage Regeneration. In LIFE-BASEL, 2022, vol. 12, no. 12, pp. Dostupné na: https://doi.org/10.3390/life12122066.