Antiproliferative effect of acridine chalcone is mediated by induction of oxidative stress

AIDY, Esraa A. - ELMONGY, Elshaymaa I. - AHMED, Abdullah A. S. - EL SAYED, Ibrahim El Tantawy - HENIDI, Hanan Ali - EL-GENDY, Saad M. - EL-GENDY, Yasmin S. - EL-TANTAWY, Ahmed Ibrahim - EFFAT, Heba. Anti-Proliferative and Apoptotic Evaluation of a Novel Synthesized Acridine Hybrid With Anticipated Synergistic Effect to Paclitaxel on Breast Cancer Cells. In CHEMICAL BIOLOGY & DRUG DESIGN, 2026, vol. 107, no. 2, pp. ISSN 1747-0277. Dostupné na: https://doi.org/10.1111/cbdd.70269.

RAI, Vipin - SRIVASTAVA, Ankit - SHEKHER, Anusmita - DUTTA, Arindam - GUPTA, Subash C. Epoxyazadiradione, a neem-derived limonoid exhibits activities against pancreatic cancer through modulation of inflammatory molecules, lncRNAs, ROS, and EMT. In BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2026, vol. 1870, no. 6, pp. ISSN 0304-4165. Dostupné na: https://doi.org/10.1016/j.bbagen.2026.130938.

DEMIREL, Gamze - TORUNOGLU, Emine Incilay - AYTAR, Erdi Can - SARI, Zeynep Betul - SARI, Muhammet Emin - DURMAZ, Alper. Antioxidant Potential, Selective Cytotoxicity, and Molecular Docking Insights of Maresia nana Methanol Extract against A549 Cancer Cells. In CHEMISTRYSELECT, 2025, vol. 10, no. 16, pp. ISSN 2365-6549. Dostupné na: https://doi.org/10.1002/slct.202406191.

FERREIRA, Maria Kueirislene Amancio - MENDES, Francisco Rogenio Silva - MARINHO, Emmanuel Silva - DE ALBUQUERQUE, Roberto Lima - GUEDES, Jesyka Macedo - TEIXEIRA, Izabell Maria Martins - DE MENEZES, Ramon Roseo Paula Pessoa Bezerra - CALDEIRA, Vinicius Patricio Santos - SANTOS, Anne Gabriella Dias - FREDERICO, Marisa Jadna Silva - BARRETO, Antonio Cesar Honorato - DOMINGUES, Ines - RODRIGUES, Tigressa Helena Soares - DE MENEZES, Jane Eire Silva Alencar - DOS SANTOS, Helcio Silva. Bioactive Chalcone-Loaded Mesoporous Silica KIT-6 Nanocarrier: A Promising Strategy for Inflammation and Pain Management in Zebrafish. In PHARMACEUTICS, 2025, vol. 17, no. 8, pp. Dostupné na: https://doi.org/10.3390/pharmaceutics17080981.

NIKOLIĆ, Ivana - LUKOVIĆ, Jovan - MARKOVIĆ, Tijana - RISTIĆ, Tijana - BULIĆ, Marija - ANĐELKOVIĆ, Marija - ŠORAK, Marija - MILINKOVIĆ, Milica - MUŠKINJA, Jovana - ČANOVIĆ, Petar - MITROVIĆ, Marina. New O-alkyl Chalcone Derivative Exhibits Antiproliferative Potential in Colorectal and Cervical Cancer Cells by Inducing G0/G1 Cell Cycle Arrest and Mitochondrial-mediated Apoptosis. Dostupné na: https://doi.org/10.2174/0109298673317485240827093121. ISSN 09298673.

ABDELAAL, Nesma - RAGHEB, Mohamed A. - HASSANEEN, Hamdi M. - ELZAYAT, Emad M. - ABDELHAMID, Ismail A. Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer. In Scientific Reports, 2024-12-01, 14, 1, pp. Dostupné na: https://doi.org/10.1038/s41598-024-76459-x.

DE SOUSA, Valgrícia Matias - DUARTE, Sâmia Sousa - SILVA, Daiana Karla Frade - FERREIRA, Rafael Carlos - DE MOURA, Ricardo Olímpio - SEGUNDO, Miguel Angelo Santos Pinheiro - FARIAS, Davi - VIEIRA, Leonardo - GONÇALVES, Juan Carlos Ramos - SOBRAL, Marianna Vieira. Cytotoxicity of a new spiro-acridine derivative: modulation of cellular antioxidant state and induction of cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma. In Naunyn-Schmiedeberg's Archives of Pharmacology, 2024-03-01, 397, 3, pp. 1901-1913. ISSN 00281298. Dostupné na: https://doi.org/10.1007/s00210-023-02686-0.

SISWANTO, Ferbian Milas - WIJAYA, Indah Mira Tiaraputri - HANDAYANI, Maria Dara Novi - DEWI, Rita - EKOWATI, Ana Lucia - MANALU, Jojor Lamsihar - NOVELYA, Novelya. Extract of Angelica keiskei Leaves Attenuates Spatial Memory Impairment on the D-galactose Model of Brain Aging in Mice. In Biomedical and Pharmacology Journal, 2024-09-01, 17, 3, pp. 1563-1573. ISSN 09746242. Dostupné na: https://doi.org/10.13005/bpj/2965.

SOUSA, Valgrícia Matias de - DUARTE, Sâmia Sousa - FERREIRA, Rafael Carlos - SOUSA, Natália Ferreira de - SCOTTI, Marcus Tullius - SCOTTI, Luciana - SILVA, Marcelo Sobral da - TAVARES, Josean Fechine - MOURA, Ricardo Olímpio de - GONÇALVES, Juan Carlos Ramos - SOBRAL, Marianna Vieira. AMTAC-19, a Spiro-Acridine Compound, Induces In Vitro Antitumor Effect via the ROS-ERK/JNK Signaling Pathway. In Molecules, 2024-11-01, 29, 22, pp. Dostupné na: https://doi.org/10.3390/molecules29225344.

WAHYUNI, Ika - AULIFA, Diah Lia - ROSDIANTO, Aziiz Mardanarian - LEVITA, Jutti. The pharmacology activities of Angelica keiskei Koidzumi and its efficacy and safety in humans. In Heliyon, 2024-01-30, 10, 2, pp. ISSN 24058440. Dostupné na: https://doi.org/10.1016/j.heliyon.2024.e24119.

XU, Sanhui - ZHAO, Yan - FU, Yongqing - LEI, Qiuxiang. Eriodictyol Inhibits Oral Cancer Proliferation and Activates ROS-mediated Apoptosis via the Attenuation of MAPK/STAT-3 Signaling Pathways. In IRANIAN RED CRESCENT MEDICAL JOURNAL, 2024, vol. 26, no. 1, pp. ISSN 2074-1804. Dostupné na: https://doi.org/10.22034/ircmj.2025.446442.1047.

KUMARA, Karthik - JYOTHI, Mahima - KOUSER, Salma - KUMAR, A. H. Uday - WARAD, Ismail - KHANUM, Shaukath Ara - LOKANATH, Neratur Krishnappagowda. Structural investigations and theoretical insights of a polymethoxy chalcone derivative: Synthesis, crystal structure, 3D energy frameworks and SARS CoV-2 docking studies. In JOURNAL OF MOLECULAR STRUCTURE, 2023, vol. 1272, no., pp. ISSN 0022-2860. Dostupné na: https://doi.org/10.1016/j.molstruc.2022.134226.

LIN, Xiaoyu - XING, Sunhui - CHEN, Kejie - YANG, Huamao - HU, Xiaoqu. Flavokavain C Suppresses Breast Cancer Cell Viability and Induces Cell Apoptosis by Triggering DNA Damage. In Biological and Pharmaceutical Bulletin, 2023-05-01, 46, 5, pp. 684-692. ISSN 09186158. Dostupné na: https://doi.org/10.1248/BPB.B22-00760.

PATAN, Afroz - AANANDHI M, Vijey - GOPINATH, P. Molecular dynamics simulation approach of hybrid chalcone-thiazole complex derivatives for DNA gyrase B inhibition: lead generation. In RSC Advances, 2023-08-14, 13, 35, pp. 24291-24308. Dostupné na: https://doi.org/10.1039/d3ra00732d.

VARAKUMAR, Potlapati - RAJAGOPAL, Kalirajan - APARNA, Baliwada - RAMAN, Kannan - BYRAN, Gowramma - GONCALVES LIMA, Clara Mariana - RASHID, Salma - NAFADY, Mohammed H. - EMRAN, Talha Bin - WYBRANIEC, Slawomir. Acridine as an Anti-Tumour Agent: A Critical Review. In MOLECULES, 2023, vol. 28, no. 1, pp. Dostupné na: https://doi.org/10.3390/molecules28010193.

YANG, Jiahui - LV, Jianmei - CHENG, Shuxian - JING, Tingyu - MENG, Tenghao - HUO, Dezhen - MA, Xin - WEN, Ran. Recent Progresses in Chalcone Derivatives as Potential Anticancer Agents. In Anti-Cancer Agents in Medicinal Chemistry, 2023-01-01, 23, 11, pp. 1265-1283. ISSN 18715206. Dostupné na: https://doi.org/10.2174/1871520623666230223112530.

ZHANG, Haibo - MA, Lei - KIM, Eungyung - YI, Junkoo - HUANG, Hai - KIM, Hyeonjin - RAZA, Muhammad Atif - PARK, Sijun - JANG, Soyoung - KIM, Kirim - KIM, Sung-Hyun - LEE, Youngkyun - KIM, Eunkyong - RYOO, Zae Young - KIM, Myoung Ok. Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo. In INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, vol. 24, no. 10, pp. ISSN 1661-6596. Dostupné na: https://doi.org/10.3390/ijms24108507.

CHUANG, Ya-Ting - SHIAU, Jun-Ping - YEN, Ching-Yu - HOU, Ming-Feng - JENG, Jiiang-Huei - TANG, Jen-Yang - CHANG, Hsueh-Wei. Fucoidan/UVC Combined Treatment Exerts Preferential Antiproliferation in Oral Cancer Cells but Not Normal Cells. In ANTIOXIDANTS, 2022, vol. 11, no. 9, pp. Dostupné na: https://doi.org/10.3390/antiox11091797.

HALIM, Peter A. - HASSAN, Rasha A. - MOHAMED, Khaled O. - HASSANIN, Soha O. - KHALIL, Mona G. - ABDOU, Amr M. - OSMAN, Eman O. Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer. In JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. ISSN 1475-6366, 2022, vol. 37, no. 1, pp. 189-201. Dostupné na: https://doi.org/10.1080/14756366.2021.1998023.

HUSSEIN, Kawkab - SHIHAB, Nezar - SAEED, Bahjat. Anti-Cancer, Anti-Osteoporosis, and Molecular Docking Studies of Novel Chalcone and Epoxy Chalcone. In BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY. ISSN 2069-5837, 2022, vol. 12, no. 5, pp. 6668-6685. Dostupné na: https://doi.org/10.33263/BRIAC125.66686685.